The Immunobiology of viral arthritides

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Title The Immunobiology of viral arthritides
Author Suhrbier, Andreas; Mahalingam, Suresh
Journal Name Pharmacology and Therapeutics
Editor S.J.Enna
Year Published 2009
Place of publication USA
Publisher Elsevier
Abstract A large range of human viruses are associated with the development of arthritis or arthralgia. Although there are many parallels with autoimmune arthritides, there is little evidence that viral arthritides lead to autoimmune disease. In humans viral arthritides usually last from weeks to months, can be debilitating, and are usually treated with non-steroidal anti-inflammatory drugs, but with variable success. Viral arthritides likely arise from immunopathological inflammatory responses directed at viruses and/or their products residing and/or replicating within joint tissues. Macrophages recruited by monocyte chemoattractant protein-1 (MCP-1/CCL2) and activated by interferon, and proinflammatory mediators like tumour necrosis factor α, interferon γ, interleukin-6 and interleukin-1β appear to be common elements in this group of diseases. The challenge for new treatments is to target excessive inflammation without compromising anti-viral immunity. Recent evidence from mouse models suggests targeting MCP-1 or complement may emerge as viable new treatment options for viral arthritides.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.pharmthera.2009.09.005
Volume 124
Issue Number 3
Page from 301
Page to 308
ISSN 0163-7258
Date Accessioned 2011-03-17
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Medical Virology
URI http://hdl.handle.net/10072/37879
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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