Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells

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Title Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
Author Santisteban, Marta; Reiman, Jennifer M.; Asiedu, Michael K.; Behrens, Marshall D.; Nassar, Aziza; Kalli, Kimberly R.; Haluska, Paul; Ingle, James N.; Hartmann, Lynn C.; Manjili, Masoud H.; Radisky, Derek; Ferrone, Soldano; Knutson, Keith
Journal Name Cancer Research
Year Published 2009
Place of publication United States
Publisher American Association for Cancer Research
Abstract The breast cancer stem cell (BCSC) hypotheses suggest that breast cancer is derived from a single tumor-initiating cell with stem-like properties, but the source of these cells is unclear. We previously observed that induction of an immune response against an epithelial breast cancer led in vivo to the T-cell–dependent outgrowth of a tumor, the cells of which had undergone epithelial to mesenchymal transition (EMT). The resulting mesenchymal tumor cells had a CD24-/loCD44+ phenotype, consistent with BCSCs. In the present study, we found that EMT was induced by CD8 T cells and the resulting tumors had characteristics of BCSCs, including potent tumorigenicity, ability to reestablish an epithelial tumor, and enhanced resistance to drugs and radiation. In contrast to the hierarchal cancer stem cell hypothesis, which suggests that breast cancer arises from the transformation of a resident tissue stem cell, our results show that EMT can produce the BCSC phenotype. These findings have several important implications related to disease progression and relapse.
Peer Reviewed Yes
Published Yes
Alternative URI
Volume 69
Issue Number 7
Page from 2887
Page to 2895
ISSN 1538-7445
Date Accessioned 2011-03-16
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Tumour Immunology
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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