Whole parasite blood stage malaria vaccines A convergence of evidence

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Title Whole parasite blood stage malaria vaccines A convergence of evidence
Author McCarthy, James S.; Good, Michael Francis
Journal Name Human Vaccines
Year Published 2010
Place of publication United States
Publisher Landes Bioscience
Abstract There is a growing realization of the limitations of recombinant protein-based malaria vaccines. This, coupled with a better understanding of the protective immunity to malaria, both in animal models and in naturally exposed human populations and experimentally infected volunteers, as well as the increased capacity to manipulate parasites provides new impetus to evaluate whole blood stage parasite approaches to malaria vaccine development. In this review previous studies in rodents and primates of whole killed and attenuated blood stage vaccines, and recent work on the effect of genetically attenuated parasites on immunity in rodent models of blood stage immunity are discussed. The relationship between these findings and what is now known about protective immunity in human populations, specifically against the blood stages of the parasite lifecycle is discussed and recent findings from human experimental infection are be reviewed. Finally, the prospect for and impediments to the development whole blood stage parasites are reviewed
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.4161/hv.6.1.10394
Volume 6
Issue Number 1
Page from 114
Page to 123
ISSN 1554-8600
Date Accessioned 2011-03-29
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Diseases
URI http://hdl.handle.net/10072/37995
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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