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dc.contributor.authorRuhayel, Rasha A
dc.contributor.authorCorry, Ben
dc.contributor.authorBraun, Carlos
dc.contributor.authorThomas, Donald S
dc.contributor.authorBerners-Price, Susan J
dc.contributor.authorFarrell, Nicholas P
dc.date.accessioned2018-02-13T03:18:19Z
dc.date.available2018-02-13T03:18:19Z
dc.date.issued2010
dc.date.modified2011-04-08T04:48:10Z
dc.identifier.issn0020-1669
dc.identifier.doi10.1021/ic100576k
dc.identifier.urihttp://hdl.handle.net/10072/38083
dc.description.abstractTwo-dimensional (2D) [1H, 15N] heteronuclear single-quantum coherence (HSQC) NMR experiments of the kinetics of aquation and sulfation of the dinuclear platinum anticancer complex [{trans-PtCl(NH3)2}2(μ-NH2(CH2)6NH2)]2+ (1,1/t,t, 1) in 15 mM sulfate solution are reported using conditions (298 K, pH 5.4) identical to those previously used for other anionic systems (phosphate and acetate), allowing for a direct comparison. Sulfate is the fourth most abundant anion in human plasma. The rate constant for the aquation step (kH) is higher than that previously found in the presence of phosphate, but the anation rate constants are similar. The rate constant for sulfate displacement of the aqua ligand (kL) is approximately three times higher than that of phosphate, and a further major difference between these two anions is the very high k−L for loss of sulfate, suggesting that when formed in plasma the sulfato species will be substitution labile. We also introduce a novel (free) plug-in, ‘2D NMR analysis’, developed for the expedited integration and analysis of 2D [1H, 15N] HSQC NMR spectra. We have found that this plug-in significantly reduces the amount of time taken in the analysis of experiments with no loss to the quality of the data.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom10815
dc.relation.ispartofpageto10819
dc.relation.ispartofissue23
dc.relation.ispartofjournalInorganic Chemistry
dc.relation.ispartofvolume49
dc.relation.urihttp://purl.org/au-research/grants/ARC/DP1095383
dc.relation.grantIDDP1095383
dc.relation.fundersARC
dc.rights.retentionY
dc.subject.fieldofresearchInorganic chemistry
dc.subject.fieldofresearchBioinorganic chemistry
dc.subject.fieldofresearchPhysical chemistry
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchcode3402
dc.subject.fieldofresearchcode340201
dc.subject.fieldofresearchcode3406
dc.subject.fieldofresearchcode3499
dc.titleDetermination of the Kinetic Profile of a Dinuclear Platinum Anticancer Complex in the Presence of Sulfate: Introducing a New Tool for the Expedited Analysis of 2D [1H, 15N] HSQC NMR Spectra
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorBerners-Price, Sue J.


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