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dc.contributor.authorHammond, MEH
dc.contributor.authorHayes, DF
dc.contributor.authorDowsett, M
dc.contributor.authorAllred, DC
dc.contributor.authorHagerty, KL
dc.contributor.authorBadve, S
dc.contributor.authorFitzgibbons, PL
dc.contributor.authorFrancis, G
dc.contributor.authorGoldstein, NS
dc.contributor.authorHayes, M
dc.contributor.authorHicks, DG
dc.contributor.authorLester, S
dc.contributor.authorLove, R
dc.contributor.authorMangu, PB
dc.contributor.authorMcshane, L
dc.contributor.authorMiller, K
dc.contributor.authorOsborne, CK
dc.contributor.authorPaik, S
dc.contributor.authorPerlmutter, J
dc.contributor.authorRhodes, A
dc.contributor.authorSasano, H
dc.contributor.authorSchwartz, JN
dc.contributor.authorSweep, FCG
dc.contributor.authorTaube, S
dc.contributor.authorTorlakovic, EE
dc.contributor.authorValenstein, P
dc.contributor.authorViale, G
dc.contributor.authorVisscher, D
dc.contributor.authorWheeler, T
dc.contributor.authorWilliams, RB
dc.contributor.authorWittliff, JL
dc.contributor.authorWolff, AC
dc.date.accessioned2017-05-03T14:19:07Z
dc.date.available2017-05-03T14:19:07Z
dc.date.issued2010
dc.date.modified2011-07-22T06:35:58Z
dc.identifier.issn0003-9985
dc.identifier.urihttp://hdl.handle.net/10072/38103
dc.description.abstractPurpose.-To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers. Methods.-The American Society of Clinical Oncology and the College of American Pathologists convened an international Expert Panel that conducted a systematic review and evaluation of the literature in partnership with Cancer Care Ontario and developed recommendations for optimal IHC ER/PgR testing performance. Results.-Up to 20% of current IHC determinations of ER and PgR testing worldwide may be inaccurate (false negative or false positive). Most of the issues with testing have occurred because of variation in preanalytic variables, thresholds for positivity, and interpretation criteria. Recommendations.-The Panel recommends that ER and PgR status be determined on all invasive breast cancers and breast cancer recurrences. A testing algorithm that relies on accurate, reproducible assay performance is proposed. Elements to reliably reduce assay variation are specified. It is recommended that ER and PgR assays be considered positive if there are at least 1% positive tumor nuclei in the sample on testing in the presence of expected reactivity of internal (normal epithelial elements) and external controls. The absence of benefit from endocrine therapy for women with ER-negative invasive breast cancers has been confirmed in large overviews of randomized clinical trials.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent333684 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherCollege of American Pathologists
dc.publisher.placeUnited States
dc.publisher.urihttps://meridian.allenpress.com/aplm/article/134/7/e48/461076/American-Society-of-Clinical-Oncology-College-of
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom907
dc.relation.ispartofpageto922 and 1101
dc.relation.ispartofissue7
dc.relation.ispartofjournalArchives of Pathology and Laboratory Medicine
dc.relation.ispartofvolume134
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleAmerican Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2010 College of American Pathologists. The attached file is provided with permission from Archives of Pathology & Laboratory Medicine. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorFrancis, Glenn D.


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