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dc.contributor.authorHammond, MEH
dc.contributor.authorHayes, DF
dc.contributor.authorDowsett, M
dc.contributor.authorAllred, DC
dc.contributor.authorHagerty, KL
dc.contributor.authorBadve, S
dc.contributor.authorFitzgibbons, PL
dc.contributor.authorFrancis, G
dc.contributor.authorGoldstein, NS
dc.contributor.authorHayes, M
dc.contributor.authorHicks, DG
dc.contributor.authorLester, S
dc.contributor.authorLove, R
dc.contributor.authorMangu, PB
dc.contributor.authorMcShane, L
dc.contributor.authorMiller, K
dc.contributor.authorOsborne, CK
dc.contributor.authorPaik, S
dc.contributor.authorPerlmutter, J
dc.contributor.authorRhodes, A
dc.contributor.authorSasano, H
dc.contributor.authorSchwartz, JN
dc.contributor.authorSweep, FCG
dc.contributor.authorTaube, S
dc.contributor.authorTorlakovic, EE
dc.contributor.authorValenstein, P
dc.contributor.authorViale, G
dc.contributor.authorVisscher, D
dc.contributor.authorWheeler, T
dc.contributor.authorWilliams, RB
dc.contributor.authorWittliff, JL
dc.contributor.authorWolff, AC
dc.date.accessioned2017-05-03T14:19:08Z
dc.date.available2017-05-03T14:19:08Z
dc.date.issued2010
dc.date.modified2011-04-11T06:48:36Z
dc.identifier.issn0732-183X
dc.identifier.doi10.1200/JCO.2009.25.6529
dc.identifier.urihttp://hdl.handle.net/10072/38104
dc.description.abstractPurpose To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers. Methods The American Society of Clinical Oncology and the College of American Pathologists convened an international Expert Panel that conducted a systematic review and evaluation of the literature in partnership with Cancer Care Ontario and developed recommendations for optimal IHC ER/PgR testing performance. Results Up to 20% of current IHC determinations of ER and PgR testing worldwide may be inaccurate (false negative or false positive). Most of the issues with testing have occurred because of variation in preanalytic variables, thresholds for positivity, and interpretation criteria. Recommendations The Panel recommends that ER and PgR status be determined on all invasive breast cancers and breast cancer recurrences. A testing algorithm that relies on accurate, reproducible assay performance is proposed. Elements to reliably reduce assay variation are specified. It is recommended that ER and PgR assays be considered positive if there are at least 1% positive tumor nuclei in the sample on testing in the presence of expected reactivity of internal (normal epithelial elements) and external controls. The absence of benefit from endocrine therapy for women with ER-negative invasive breast cancers has been confirmed in large overviews of randomized clinical trials.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society of Clinical Oncology
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2784
dc.relation.ispartofpageto2795
dc.relation.ispartofissue16
dc.relation.ispartofjournalJournal of Clinical Oncology
dc.relation.ispartofvolume28
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3211
dc.titleAmerican Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorFrancis, Glenn D.


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