Malaria Vaccine Design: Immunological Considerations

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Title Malaria Vaccine Design: Immunological Considerations
Author Good, Michael Francis; Doolan, Denise L.
Journal Name Immunity
Year Published 2010
Place of publication United States
Publisher Cell Press
Abstract The concept of a malaria vaccine has sparked great interest for decades; however, the challenge is proving to be a difficult one. Immune dysregulation by Plasmodium and the ability of the parasite to mutate critical epitopes in surface antigens have proved to be strong defense weapons. This has led to reconsideration of polyvalent and whole parasite strategies and ways to enhance cellular immunity to malaria that may be more likely to target conserved antigens and an expanded repertoire of antigens. These and other concepts will be discussed in this review.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.immuni.2010.10.005
Volume 33
Issue Number 4
Page from 555
Page to 566
ISSN 1074-7613
Date Accessioned 2011-01-31
Date Available 2011-04-11T06:48:52Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Griffith Health Faculty
Subject Immunology
URI http://hdl.handle.net/10072/38106
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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