Restricted Semliki Forest virus replication in Perforin and Fas-ligand double deficient mice
Author(s)
Alsharifi, Mohammed
Lobigs, Mario
Bettadapura, Jayaram
Koskinen, Aulikki
Müllbacher, Arno
Griffith University Author(s)
Year published
2008
Metadata
Show full item recordAbstract
Previously, we have shown that mice defective in granule exocytosis and/or Fas.L/Fas-mediated cytolytic pathways are significantly more resistant to alphavirus, Semliki Forest virus (SFV), infection compared with wild-type mice. Here, we evaluated SFV replication in different tissues of mice defective in both cytolytic pathways (perf-/-xgld) relative to that in wild-type counterparts and found that viral replication in perf-/-xgld mice is remarkably restricted. Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic ...
View more >Previously, we have shown that mice defective in granule exocytosis and/or Fas.L/Fas-mediated cytolytic pathways are significantly more resistant to alphavirus, Semliki Forest virus (SFV), infection compared with wild-type mice. Here, we evaluated SFV replication in different tissues of mice defective in both cytolytic pathways (perf-/-xgld) relative to that in wild-type counterparts and found that viral replication in perf-/-xgld mice is remarkably restricted. Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic effector molecules in antiviral immunity needs to be re-evaluated.
View less >
View more >Previously, we have shown that mice defective in granule exocytosis and/or Fas.L/Fas-mediated cytolytic pathways are significantly more resistant to alphavirus, Semliki Forest virus (SFV), infection compared with wild-type mice. Here, we evaluated SFV replication in different tissues of mice defective in both cytolytic pathways (perf-/-xgld) relative to that in wild-type counterparts and found that viral replication in perf-/-xgld mice is remarkably restricted. Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic effector molecules in antiviral immunity needs to be re-evaluated.
View less >
Journal Title
Journal of General Virology
Volume
89
Subject
Medical Virology
Biological Sciences
Agricultural and Veterinary Sciences
Medical and Health Sciences