Molecular and cellular mechanisms in the viral exacerbation of asthma

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Title Molecular and cellular mechanisms in the viral exacerbation of asthma
Author Tauro, Sharyn; Su, Yung-Chan; Thomas, Sandra; Schwarze, Yurgen; Matthaei, Klaus I.; Townsend, Dijana; Simson, Ljubov; Tripp, Ralph A.; Mahalingam, Suresh
Journal Name Microbes and Infection
Year Published 2008
Place of publication France
Publisher Elsevier Masson
Abstract The aetiology of asthma associated with viral infection is complex. The dynamics that contribute to disease pathogenesis are multifactorial and involve overlapping molecular and cellular mechanisms, particularly the immune response to respiratory virus infection or allergen sensitization. This review summarizes the evidence associated with factors that may contribute to the development or exacerbation of asthma including age, host factors, genetic polymorphisms, altered immune responses, and aspects of viral antigen expression. This review also provides an important perspective of key events linked to the development of asthmatic disease and related pulmonary inflammation from human and animal studies, and discusses their relationship as targets for disease intervention strategies.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.micinf.2008.07.037
Volume 10
Issue Number 9
Page from 1014
Page to 1023
ISSN 1286-4579
Date Accessioned 2011-04-06
Date Available 2011-05-03T04:46:48Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Cellular Immunology; Virology
URI http://hdl.handle.net/10072/38527
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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