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dc.contributor.authorKote-Jarai, Zsofia
dc.contributor.authorEaston, Douglas F
dc.contributor.authorStanford, Janet L
dc.contributor.authorOstrander, Elaine A
dc.contributor.authorSchleutker, Johanna
dc.contributor.authorIngles, Sue A
dc.contributor.authorSchaid, Daniel
dc.contributor.authorThibodeau, Stephen
dc.contributor.authorDoerk, Thilo
dc.contributor.authorNeal, David
dc.contributor.authorCox, Angela
dc.contributor.authorMaier, Christiane
dc.contributor.authorVogel, Walter
dc.contributor.authorGuy, Michelle
dc.contributor.authorMuir, Kenneth
dc.contributor.authorLophatananon, Artitaya
dc.contributor.authorKedda, Mary-Anne
dc.contributor.authorSpurdle, Amanda
dc.contributor.authorSteginga, Suzanne
dc.contributor.authorJohn, Esther M
dc.contributor.authorGiles, Graham
dc.contributor.authorHopper, John
dc.contributor.authorChappuis, Pierre O
dc.contributor.authorHutter, Pierre
dc.contributor.authorFoulkes, William D
dc.contributor.authorHamel, Nancy
dc.contributor.authorSalinas, Claudia A
dc.contributor.authorKoopmeiners, Joseph S
dc.contributor.authorKaryadi, Danielle M
dc.contributor.authorJohanneson, Bo
dc.contributor.authorWahlfors, Tiina
dc.contributor.authorTammela, Teuvo L
dc.contributor.authorStern, Mariana C
dc.contributor.authorCorral, Roman
dc.contributor.authorMcDonnell, Shannon K
dc.contributor.authorSchuermann, Peter
dc.contributor.authorMeyer, Andreas
dc.contributor.authorKuefer, Rainer
dc.contributor.authorLeongamornlert, Daniel A
dc.contributor.authorTymrakiewicz, Malgorzata
dc.contributor.authorLiu, Jo-fen
dc.contributor.authorO'Mara, Tracy
dc.contributor.authorGardiner, RA Frank
dc.contributor.authorAitken, Joanne
dc.contributor.authorJoshi, Amit D
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorEnglish, Dallas R
dc.contributor.authorSouthey, Melissa
dc.contributor.authorEdwards, Stephen M
dc.contributor.authorAl Olama, Ali Amin
dc.contributor.authorEeles, Rosalind A
dc.contributor.editorTimothy R. Rebbeck, Ph.D., Editor-in-Chief
dc.date.accessioned2017-05-03T14:36:59Z
dc.date.available2017-05-03T14:36:59Z
dc.date.issued2008
dc.identifier.issn1055-9965
dc.identifier.doi10.1158/1055-9965.EPI-08-0317
dc.identifier.urihttp://hdl.handle.net/10072/38542
dc.description.abstractA recent genome-wide association study found that genetic variants on chromosomes 3, 6, 7, 10, 11, 19 and X were associated with prostate cancer risk. We evaluated the most significant single-nucleotide polymorphisms (SNP) in these loci using a worldwide consortium of 13 groups (PRACTICAL). Blood DNA from 7,370 prostate cancer cases and 5,742 male controls was analyzed by genotyping assays. Odds ratios (OR) associated with each genotype were estimated using unconditional logistic regression. Six of the seven SNPs showed clear evidence of association with prostate cancer (P = 0.0007-P = 10-17). For each of these six SNPs, the estimated per-allele OR was similar to those previously reported and ranged from 1.12 to 1.29. One SNP on 3p12 (rs2660753) showed a weaker association than previously reported [per-allele OR, 1.08 (95% confidence interval, 1.00-1.16; P = 0.06) versus 1.18 (95% confidence interval, 1.06-1.31)]. The combined risks associated with each pair of SNPs were consistent with a multiplicative risk model. Under this model, and in combination with previously reported SNPs on 8q and 17q, these loci explain 16% of the familial risk of the disease, and men in the top 10% of the risk distribution have a 2.1-fold increased risk relative to general population rates. This study provides strong confirmation of these susceptibility loci in multiple populations and shows that they make an important contribution to prostate cancer risk prediction. (Cancer Epidemiol Biomarkers Prev 2008;17(8):2052-61)
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Association for Cancer Research
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2052
dc.relation.ispartofpageto2061
dc.relation.ispartofissue8
dc.relation.ispartofjournalCancer Epidemiology, Biomarkers & Prevention
dc.relation.ispartofvolume17
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchCancer genetics
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode321103
dc.titleMultiple Novel Prostate Cancer Predisposition Loci Confirmed by an International Study: The Practical Consortium
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2014-10-10T01:56:45Z
gro.hasfulltextNo Full Text
gro.griffith.authorChambers, Suzanne K.


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