Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates

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Title Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates
Author Fujita, Yoshio; Abdel-Aal, Abu-Baker M.; Wimmer, Norbert; Batzloff, Michael Raymond; Good, Michael Francis; Toth, Istvan
Journal Name Bioorganic & medicinal chemistry.
Year Published 2008
Place of publication United Kingdom
Publisher Elsevier Science
Abstract Synthesis of four glycolipids with different number of lauroyl groups on glucose or cellobiose as scaffolds is described. Their immunological evaluations either admixed with or covalently linked to J8, a peptide antigen derived from the C-terminus of the antiphagocytic M-protein of group A streptococcus, are also investigated. Administration of mixtures of J8 and glycolipids to B10BR (H-2k) mice induced low-levels of J8-specific IgG antibodies. While glycolipopeptides, in which J8 was covalently linked to the synthetic glycolipids, demonstrated high-levels of antibody titers comparable with the co-administration of these glycolipopeptides with complete Freund’s adjuvant, suggesting clearly the strong potency of the synthesized glycolipids as self-adjuvanting moieties.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.bmc.2008.08.064
Volume 16
Issue Number 19
Page from 8907
Page to 8913
ISSN 0968-0896
Date Accessioned 2011-03-21
Language en_US
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Agents
URI http://hdl.handle.net/10072/38544
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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