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dc.contributor.authorC. D⿿Ombrain, Marthe
dc.contributor.authorJ. Robinson, Leanne
dc.contributor.authorI. Stanisic, Danielle
dc.contributor.authorTaraika, Jack
dc.contributor.authorBernard, Nicholas
dc.contributor.authorMichon, Pascal
dc.contributor.authorMueller, Ivo
dc.contributor.authorSchofield, Louis
dc.date.accessioned2017-05-03T16:01:43Z
dc.date.available2017-05-03T16:01:43Z
dc.date.issued2008
dc.date.modified2011-09-14T06:18:24Z
dc.identifier.issn10584838
dc.identifier.doi10.1086/592971
dc.identifier.urihttp://hdl.handle.net/10072/38545
dc.description.abstractBackground. Elucidating the cellular and molecular basis of naturally acquired immunity to Plasmodium falciparum infection would assist in developing a rationally based malaria vaccine. Innate, intermediate, and adaptive immune mechanisms are all likely to contribute to immunity. Interferon-g (IFN-g) has been implicated in both protection against and the pathogenesis of malaria in humans. In addition, considerable heterogeneity exists among rapid IFN-g responses to P. falciparum in malaria-naive donors. The question remains whether similar heterogeneity is observed in malaria-exposed individuals and whether high, medium, or low IFN-g responsiveness is differentially associated with protective immunity or morbidity. Methods. A 6-month longitudinal cohort study involving 206 school-aged Papua New Guinean children was performed. Peripheral blood mononuclear cells collected at baseline were exposed to live P. falciparum-infected erythrocytes. Early IFN-g responses were measured, and IFN-g-expressing cells were characterized by flow cytometry. IFN-g responsiveness was then tested for associations with parasitological and clinical outcome variables. Results. Malaria-specific heterogeneity in early IFN-g responsiveness was observed among children. High-level early IFN-g responses were associated with protection from high-density and clinical P. falciparum infections. Parasite-induced early IFN-g was predominantly derived from gd T cells (68% of which expressed the natural killer marker CD56) and ab T cells, whereas natural killer cells and other cells made only minor contributions. The expression of CD56 in malaria-responsive, IFN-g-expressing gd T cells correlated with IFN-g responsiveness. Conclusions. High, early IFN-g production by live parasite-stimulated peripheral blood mononuclear cells is a correlate of immunity to symptomatic malaria in Papua New Guinean children, and natural killer-like gd T cells may contribute to protection.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent497535 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1380
dc.relation.ispartofpageto1387
dc.relation.ispartofissue11
dc.relation.ispartofjournalClinical Infectious Diseases
dc.relation.ispartofvolume47
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchCellular immunology
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320404
dc.titleAssociation of early interferon-γ production with immunity to clinical malaria: a longitudinal study among Papua New Guinean children
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2008 by University of Chicago Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. First published in Clinical Infectious Diseases with publishing partner Infectious Diseases Society of America. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2008
gro.hasfulltextFull Text
gro.griffith.authorStanisic, Danielle


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