What have we learnt from mouse models for the study of malaria?

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Title What have we learnt from mouse models for the study of malaria?
Author Wykes, Michelle N.; Good, Michael Francis
Journal Name European Journal of Immunology
Year Published 2009
Place of publication Germany
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Abstract Malaria is a serious cause of morbidity and mortality and yet a vaccine is not available. Studies have used animal models to understand the pathogenesis of disease and a large amount of data on parasite biology, immune regulation and disease processes have been gained from these studies. Moreover, these models have been used for pre-clinical testing of various drugs and vaccines. Here, we discuss the features of various mouse models used to study the immunobiology of malaria and test pre-clinical vaccines and conclude that animal models have a role in the study of malaria but the experimental conditions used for testing must reflect the environment of infected individuals.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1002/eji.200939552
Volume 39
Issue Number 8
Page from 2004
Page to 2007
ISSN 0014-2980
Date Accessioned 2011-03-31
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Diseases
URI http://hdl.handle.net/10072/38919
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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