Acute but not chronic caffeine impairs functional responses to ischaemia-reperfusion in rat isolated perfused heart.

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Title Acute but not chronic caffeine impairs functional responses to ischaemia-reperfusion in rat isolated perfused heart.
Author Rose'Meyer, Roselyn; Headrick, John Patrick; Peart, Jason Nigel John; Harrison, Glenn; Garnham, Bronwyn Gaye; Willis, Roger
Journal Name Clinical and Experimental Pharmacology & Physiology
Editor Warwick P Anderson
Year Published 2001
Place of publication Australia
Publisher Blackwell Publishing
Abstract 1. The effect of acute (50 ¼mol/L) and chronic (0.06% in drinking water for 14 days) caffeine on the response to ischaemiareperfusion was studied in Wistar rat isolated perfused hearts. 2. Neither acute nor chronic caffeine modified normoxic heart rate or left ventricular pressures. However, acute caffeine decreased coronary flow by up to 20%, while chronic caffeine consumption increased coronary flow by approximately 15% and abolished the vasoconstrictor effect of acute caffeine (P< 0.05). 3. After 15 min global ischaemia, chronic caffeine treatment did not alter the recovery of left ventricular diastolic pressure (LVDP), end-diastolic pressure (EDP) or heart rate during reperfusion, but did enhance coronary flow rate (P< 0.05). Acute caffeine inhibited the recovery of LVDP and elevated postischaemic EDP in both caffeine-naïve and chronic caffeine-treated groups. Acute caffeine also significantly inhibited coronary reflow in naïve but not chronic caffeine-treated groups and produced a transient tachycardia during reperfusion in hearts from chronic caffeine-treated rats. 4. The incidence of arrhythmias was unaltered by chronic caffeine treatment, but was increased by acute caffeine in both naïve and chronic caffeine hearts. 5. In conclusion, chronic caffeine intake alone has no detrimental effects on recovery from ischaemia; however, acute caffeine worsens postischaemic contractile function in hearts from naïve and chronic caffeine-treated rats.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.blackwell-synergy.com/doi/full/10.1046/j.1440-1681.2001.03389.x
Alternative URI http://www.blackwell-synergy.com/links/doi/10.1046%2Fj.1440-1681.2001.03389.x
Copyright Statement Copyright 2001 Blackwell Publishing. The definitive version is available at [www.blackwell-synergy.com.]
Volume 28
Page from 19
Page to 24
ISSN 0305-1870
Date Accessioned 2002-04-11
Date Available 2007-03-14T02:28:36Z
Language en_AU
Research Centre Griffith Health Institute; Heart Foundation Research Centre
Subject Systems Physiology
URI http://hdl.handle.net/10072/3893
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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