Surgical and physical stress increase circulating blood dendritic cell counts independently of monocyte counts

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Title Surgical and physical stress increase circulating blood dendritic cell counts independently of monocyte counts
Author Ho, Christopher S. K.; Lopez, J. Alejandro; Vuckovic, Slavica; Pyke, Christopher M.; Hockey, Richard L.; Hart, Derek N. J.
Journal Name Blood
Year Published 2001
Place of publication United States
Publisher American Society of Hematology
Abstract Dendritic cells (DCs) are specialized antigen-presenting cells that have the unique ability to initiate a primary immune response. The effect of physiologic stress on circulating blood DCs has thus far not been studied. In this study, we applied a recently developed method of counting blood DCs to test the hypothesis that significant stress to the body such as surgery and exercise might induce measurable changes in the DC numbers, subsets, phenotype, and function. Twenty-six patients scheduled for elective laparoscopic cholecystectomy, 4 for elective hysterectomy, 56 controls, and 5 volunteers who underwent a stress exercise test were enrolled in the study. Absolute DC counts increased acutely (71.7% 6 11% [SEM], P 5 .0001) in response to the stress of surgery and dropped below preoperative levels (225% 6 14% [SEM], P 5 .05) on days 2-3. The perioperative DC subset balance remained constant. Interestingly, DC counts changed independently ofmonocytecounts. Exercise also induced a rise in DC counts but coincidentally with monocyte counts. Surprisingly, no phenotypic or functional activation of DCs was seen in either stress situations in vivo. DCs are rapidly mobilized into the circulation in response to surgical and exercise stress, which may serve to prepare the host's immune defenses against trauma. The independent regulation of the DC and monocyte counts reinforces the distinction between these 2 cell populations.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1182/blood.V98.1.140
Volume 98
Issue Number 1
Page from 140
Page to 145
ISSN 0006-4971
Date Accessioned 2011-05-10
Date Available 2011-06-28T06:45:29Z
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Cellular Immunology
URI http://hdl.handle.net/10072/39264
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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