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dc.contributor.authorCampbell, Bronwyn E
dc.contributor.authorBoag, Peter R
dc.contributor.authorHofmann, Andreas
dc.contributor.authorCantacessi, Cinzia
dc.contributor.authorWang, Conan K
dc.contributor.authorTaylor, Paul
dc.contributor.authorHu, Min
dc.contributor.authorSindhu, Zia-ud-Din
dc.contributor.authorLoukas, Alex
dc.contributor.authorSternberg, Paul W
dc.contributor.authorGasser, Robin B
dc.date.accessioned2017-05-03T15:18:57Z
dc.date.available2017-05-03T15:18:57Z
dc.date.issued2011
dc.date.modified2011-08-09T06:27:34Z
dc.identifier.issn0734-9750
dc.identifier.doi10.1016/j.biotechadv.2011.01.006
dc.identifier.urihttp://hdl.handle.net/10072/39787
dc.description.abstractAlmost nothing is known about atypical kinases in multicellular organisms, including parasites. Supported by information and data available for the free-living nematode, Caenorhabditis elegans, and other eukaryotes, the present article describes three RIO kinase genes, riok-1, riok-2 and riok-3, from Haemonchus contortus, one of the most important parasitic nematodes of small ruminants. Analyses of these genes and their products predict that they each play critical roles in the developmental pathways of parasitic nematodes. The findings of this review indicate prospects for functional studies of these genes in C. elegans (as a surrogate) and opportunities for the design of a novel class of nematode-specific inhibitors of RIO kinases. The latter aspect is of paramount importance, given the serious problems linked to anthelmintic resistance in parasitic nematode populations of livestock.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent239848 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom338
dc.relation.ispartofpageto350
dc.relation.ispartofissue3
dc.relation.ispartofjournalBiotechnology Advances
dc.relation.ispartofvolume29
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchStructural biology (incl. macromolecular modelling)
dc.subject.fieldofresearchVeterinary parasitology
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310112
dc.subject.fieldofresearchcode300909
dc.subject.fieldofresearchcode40
dc.titleAtypical (RIO) protein kinases from Haemonchus contortus - Promise as new targets for nematocidal drugs
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2011 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorHofmann, Andreas
gro.griffith.authorWang, Conan K.


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