The toxicity of Aloe barbadensis Miller juice is due to the induction of oxidative stress

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Title The toxicity of Aloe barbadensis Miller juice is due to the induction of oxidative stress
Author Cock, Ian Edwin; P, Joseph
Publication Title The 2nd International Symposium On Medicinal Plants, Their Cultivation and Aspects of Uses
Editor Dr Mohammad Darwish
Year Published 2010
Abstract Exposure of Artemia nauplii to Aloe vera juice resulted in acute toxicity at dilutions as low as approximately 4 % (24 h LC50 4.6 % ± 0.3). All antioxidants examined were also toxic when tested in high doses with 24 h LC50's in the following order of toxicity: vitamin C (203.1 µg/ml ± 11.3) > Trolox™ (283.3 µg/ml ± 25.8) > vitamin E (only low toxicity was observed at 24 h). At lower doses, vitamin E and Trolox™ were non-toxic and could block the toxicity induced by Aloe vera juice. Vitamin E was more effective than Trolox™. Treatment of A. franciscana with antioxidants prior to exposure to juice was more effective than the simultaneous treatment of antioxidant and the toxin, suggesting that Aloe vera juice induced lethality is due to oxidative stress which can be blocked by antioxidant addition. The mechanism of Aloe vera juice toxicity was examined by measuring its effect on various biomarker enzymes. Exposure of Artemia nauplii to sub-lethal levels of Aloe vera juice resulted in a decreased activity of thioredoxin reductase, glutathione reductase and glutathione peroxidase by 34%, 79% and 90% respectively. Vitamin E co-exposure resulted in enzyme activities closer to the control value (78%, 56% and 32% of control enzymatic activities for thioredoxin reductase, glutathione reductase and glutathione peroxidase activity respectively). These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that vitamin E addition helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
Peer Reviewed No
Published Yes
Publisher URI http://ismp.bau.edu.jo/
Conference name The 2nd International Symposium On Medicinal Plants, Their Cultivation and Aspects of Uses
Location Petra Jordan
Date From 2010-11-03
Date To 2010-11-04
URI http://hdl.handle.net/10072/39797
Date Accessioned 2011-02-14
Date Available 2011-08-09T06:28:08Z
Language en_AU
Research Centre Environmental Futures Research Institute
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Biological Sciences
Publication Type Conference Publications (Extract Paper)
Publication Type Code e3

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