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dc.contributor.authorEl-Deeb, Ibrahim Mustafa
dc.contributor.authorHan, Dong Keun
dc.contributor.authorKim, In Tae
dc.contributor.authorLee, So
dc.date.accessioned2017-05-03T15:59:03Z
dc.date.available2017-05-03T15:59:03Z
dc.date.issued2010
dc.date.modified2011-08-12T06:18:43Z
dc.identifier.issn02532964
dc.identifier.doi10.5012/bkcs.2010.31.7.1848
dc.identifier.urihttp://hdl.handle.net/10072/39884
dc.description.abstractPhenylaminopyrimidines represent a large group of new selective anticancer agents, the majority of which exert their action through the inhibition of specific kinases. In this study, a new series of N-substituted-2-aminopyrimidines has been designed and synthesized. A selected group of the synthesized derivatives was screened at a single dose concentration of 10 占over a panel of 60 cancer cell-lines. Compound 12e has showed great inhibitory and strong lethal effect over almost all of the 60 cell-lines and accordingly was further tested in a 5-dose testing mode to determine its IC50 values, where it showed great efficacies with intermediate potencies over the tested cell-lines. The compound was also tested over a panel of 52 kinases to explore its kinase inhibitory profile, and was found to be a selective but moderate inhibitor over FLT3 kinase.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherKorean Chemical Society
dc.publisher.placeSouth Korea
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom1848
dc.relation.ispartofpageto1858
dc.relation.ispartofissue7
dc.relation.ispartofjournalBulletin of the Korean Chemical Society
dc.relation.ispartofvolume31
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340401
dc.titleNew Phenylaminopyrimidine (PAP) Anticancer Lead Compound with High Efficacy: Design, Synthesis, and in vitro Screening
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorEl-Deeb, Ibrahim Mustafa


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