dc.contributor.author | El-Deeb, Ibrahim Mustafa | |
dc.contributor.author | Han, Dong Keun | |
dc.contributor.author | Kim, In Tae | |
dc.contributor.author | Lee, So | |
dc.date.accessioned | 2017-05-03T15:59:03Z | |
dc.date.available | 2017-05-03T15:59:03Z | |
dc.date.issued | 2010 | |
dc.date.modified | 2011-08-12T06:18:43Z | |
dc.identifier.issn | 02532964 | |
dc.identifier.doi | 10.5012/bkcs.2010.31.7.1848 | |
dc.identifier.uri | http://hdl.handle.net/10072/39884 | |
dc.description.abstract | Phenylaminopyrimidines represent a large group of new selective anticancer agents, the majority of which exert their action through the inhibition of specific kinases. In this study, a new series of N-substituted-2-aminopyrimidines has been designed and synthesized. A selected group of the synthesized derivatives was screened at a single dose concentration of 10 占over a panel of 60 cancer cell-lines. Compound 12e has showed great inhibitory and strong lethal effect over almost all of the 60 cell-lines and accordingly was further tested in a 5-dose testing mode to determine its IC50 values, where it showed great efficacies with intermediate potencies over the tested cell-lines. The compound was also tested over a panel of 52 kinases to explore its kinase inhibitory profile, and was found to be a selective but moderate inhibitor over FLT3 kinase. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Korean Chemical Society | |
dc.publisher.place | South Korea | |
dc.relation.ispartofstudentpublication | Y | |
dc.relation.ispartofpagefrom | 1848 | |
dc.relation.ispartofpageto | 1858 | |
dc.relation.ispartofissue | 7 | |
dc.relation.ispartofjournal | Bulletin of the Korean Chemical Society | |
dc.relation.ispartofvolume | 31 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Biologically active molecules | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 340401 | |
dc.title | New Phenylaminopyrimidine (PAP) Anticancer Lead Compound with High Efficacy: Design, Synthesis, and in vitro Screening | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2010 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | El-Deeb, Ibrahim Mustafa | |