Soluble CD38 significantly prolongs the lifespan of memory B-cell responses

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Title Soluble CD38 significantly prolongs the lifespan of memory B-cell responses
Author Liu, Xue Q.; Hart, Derek N. J.; MacPherson, Gordon G.; Good, Michael Francis; Wykes, Michelle N.
Journal Name Immunology
Year Published 2008
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
Abstract The development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously shown that FDC networks within GC of the spleen express a novel ligand for CD38 and that the administration of soluble CD38 induces an expansion of these cellular structures. We therefore used adoptive transfer studies to investigate whether the expansion of FDC networks with soluble CD38 affected the generation and maintenance of antigen-specific MBC. These studies found that the administration of soluble CD38 significantly extended the period after which MBC could be activated and that the frequencies of these cells also were increased. In conclusion, soluble CD38 appears to significantly extend the lifespan of antibody memory by increasing the numbers of MBC.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1111/j.1365-2567.2008.02914.x
Volume 125
Issue Number 1
Page from 14
Page to 20
ISSN 0019-2805
Date Accessioned 2011-07-13
Date Available 2011-08-12T06:19:49Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Immunology
URI http://hdl.handle.net/10072/39909
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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