Structure–Activity Relationship of a Series of Synthetic Lipopeptide Self-Adjuvanting Group A Streptococcal Vaccine Candidates

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Title Structure–Activity Relationship of a Series of Synthetic Lipopeptide Self-Adjuvanting Group A Streptococcal Vaccine Candidates
Author Abdel-Aal, Abu-Baker M.; Batzloff, Michael R.; Fujita, Yoshio; Barozzi, Nadia; Faria, Andres; Simerska, Pavla; Moyle, Peter M.; Good, Michael Francis; Toth, Istvan
Journal Name Journal of Medicinal Chemistry
Year Published 2008
Place of publication United States
Publisher American Chemical Society
Abstract The development of 16 self-adjuvanting group A streptococcal vaccine candidates, composed of (i) a universal helper T-cell epitope (P25), (ii) a target GAS B-cell epitope (J14), and (iii) a lipid moiety, is described. Systemic J14-specific IgG antibodies were detected following subcutaneous immunization of BALB/c (H-2d) mice with each construct without the need for an additional adjuvant. The effect of changing the order of P25, J14, and lipid moiety attachment or incorporation of P25 and J14 into a lipid-core peptide system on antibody titers was assessed. The point of lipid moiety attachment had the greatest influence on systemic J14-specific IgG antibody titers. Overall, the best vaccines featured a C-terminal lipid moiety, conjugated through a lysine residue to P25 at the N-terminus, and J14 on the lysine side chain.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1021/jm701091d
Copyright Statement Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Volume 51
Issue Number 1
Page from 167
Page to 172
ISSN 0022-2623
Date Accessioned 2011-07-13
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Medicinal and Biomolecular Chemistry
URI http://hdl.handle.net/10072/39924
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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