Malaria vaccines: the case for a whole-organism approach

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Title Malaria vaccines: the case for a whole-organism approach
Author Pinzon-Charry, Alberto; Good, Michael Francis
Journal Name Expert Opinion on Biological Therapy
Year Published 2008
Place of publication United Kingdom
Publisher Informa Healthcare
Abstract Background: Malaria is a significant health problem causing morbidity and mortality worldwide. Vaccine development has been an imperative for decades. However, the intricacy of the parasite's lifecycle coupled with the lack of evidence for robust infection-induced immunity has made vaccine development exceptionally difficult. Objective: To review some of the key advances in the field and discuss potential ways forward for a whole-organism vaccine. Methods: The authors searched PubMed using the words 'malaria and vaccine'. We searched for manuscripts detailing antigen characterisation and vaccine strategies with emphasis on subunit versus whole-parasite approaches. Abstracts were selected and relevant articles are discussed. The searches were not restricted by language or date. Conclusions: The early cloning of malaria antigens has fuelled rapid development of subunit vaccines. However, the disappointing results of clinical trials have resulted in reappraisal of current strategies. Whole-parasite approaches have re-emerged as an alternative strategy. Immunization using radiation or genetically attenuated sporozoites has been shown to result in sterile immunity and immunization with blood-stage parasites curtailed by antimalarials has demonstrated delayed parasitemia in rodent models as well as in human malaria.
Peer Reviewed Yes
Published Yes
Publisher URI http://informahealthcare.com/doi/abs/10.1517/14712598.8.4.441
Volume 8
Issue Number 4
Page from 441
Page to 448
ISSN 1471-2598
Date Accessioned 2011-07-13
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Medical and Health Sciences
URI http://hdl.handle.net/10072/39925
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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