[1H,15N] NMR studies of the aquation of cis-diamine platinum(II) complexes

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Title [1H,15N] NMR studies of the aquation of cis-diamine platinum(II) complexes
Author Cubo, Leticia; Thomas, Donald S.; Zhang, Junyong; Quiroga, Adoración G.; Navarro-Ranninger, Carmen; Berners-Price, Sue
Journal Name Inorganica Chimica Acta
Year Published 2009
Place of publication Netherlands
Publisher Elsevier BV
Abstract Two 15N-labelled cis-Pt(II) diamine complexes with dimethylamine (15N-dma) and isopropylamine (15N-ipa) ligands have been prepared and characterised. [1H,15N] HSQC NMR spectroscopy is used to obtain the rate and equilibrium constants for the aquation of cis-[PtCl2(15N-dma)2] at 298 K in 0.1 M NaClO4 and to determine the pKa values of cis-[PtCl(H2O)(15N-dma)2]+ (6.37) and cis-[Pt(H2O)2(15N-dma)2]2+ (pKa1 = 5.17, pKa2 = 6.47). The rate constants for the first and second aquation steps (k1 = (2.12 ± 0.01) × 10−5 s−1, k2 = (8.7 ± 0.7) × 10−6 s−1) and anation steps (k−1 = (6.7 ± 0.8) × 10−3 M−1 s−1, k−2 = 0.043 ± 0.004 M−1 s−1) are very similar to those reported for cisplatin under similar conditions, and a minor difference is that slow formation of the hydroxo-bridged dimer is observed. Aquation studies of cis-[PtCl2(15N-ipa)2] were precluded by the close proximity of the NH proton signal to the 1H2O resonance.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.ica.2008.03.117
Volume 362
Issue Number 3
Page from 1022
Page to 1026
ISSN 0020-1693
Date Accessioned 2011-07-15
Date Available 2011-08-12T06:20:30Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Inorganic Chemistry
URI http://hdl.handle.net/10072/39931
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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