What really happens to dendritic cells during malaria?

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Title What really happens to dendritic cells during malaria?
Author Wykes, Michelle N.; Good, Michael Francis
Journal Name Nature Reviews Microbiology
Year Published 2008
Place of publication United Kingdom
Publisher Nature Publishing Group
Abstract As dendritic cells (DCs) initiate all adaptive and some innate immune responses, it is not surprising that DC function during malaria is the subject of intensive investigations. However, the results of these investigations have so far been controversial. Here, we discuss various aspects of these studies, including the influence of the species and strain of Plasmodium on DC function, the effects of Plasmodium infection on the activation of CD8+ T cells by DCs, the effects of haemozoin and the effects of Plasmodium infections on DC Toll-like-receptor signalling.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1038/nrmicro1988
Volume 6
Issue Number 11
Page from 864
Page to 870
ISSN 1740-1526
Date Accessioned 2011-07-13
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Microbiology
URI http://hdl.handle.net/10072/39939
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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