emm and C-Repeat Region Molecular Typing of Beta-Hemolytic Streptococci in a Tropical Country: Implications for Vaccine Development

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Title emm and C-Repeat Region Molecular Typing of Beta-Hemolytic Streptococci in a Tropical Country: Implications for Vaccine Development
Author Steer, Andrew C.; Magor, Graham; Jenney, Adam W. J.; Kado, Joseph; Good, Michael Francis; McMillan, David; Batzloff, Michael; Carapetis, Jonathan R.
Journal Name Journal of Clinical Microbiology
Year Published 2008
Place of publication United States
Publisher American Society for Microbiology
Abstract We designed a study to investigate the molecular epidemiology of group A streptococcal (GAS) and group C and G streptococcal (GCS and GGS) disease in Fiji, a country which is known to have a high burden of streptococcal disease. Molecular typing of the N-terminal portion (emm typing) of the M protein was performed with 817 isolates (535 GAS and 282 GCS/GGS). We also performed genotyping of the C-repeat region in 769 of these isolates to identify J14 sequence types. The profile of emm types for Fiji was very different from that found for the United States and Europe. There were no dominant emm types and a large number of overlapping types among clinical disease states. Commonly found GAS emm types in industrialized countries, including emm1, emm12, and emm28, were not found among GAS isolates from Fiji. Over 93% of GAS isolates and over 99% of GCS/GGS isolates that underwent J14 sequence typing contained either J14.0 or J14.1. Our data have implications for GAS vaccine development in developing countries and suggest that a vaccine based upon the conserved region of the M protein may be a feasible option for Fiji and potentially for other tropical developing countries.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1128/JCM.00312-09
Volume 47
Issue Number 8
Page from 2502
Page to 2509
ISSN 0095-1137
Date Accessioned 2011-07-14
Date Available 2011-08-12T06:21:24Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Microbiology
URI http://hdl.handle.net/10072/39960
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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