Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine

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Title Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine
Author Zaman, Mehfuz; Skwarczynski, Mariusz; Malcolm, Jessica M.; Urbani, Carl N.; Jia, Zhongfan; Batzloff, Michael R.; Good, Michael Francis; Monteiro, Michael J.; Toth, Istvan
Journal Name Nanomedicine: Nanotechnology, Biology and Medicine
Year Published 2011
Place of publication United Kingdom
Publisher Elsevier
Abstract Infection with Streptococcus pyogenes, commonly known as group A Streptococcus (GAS), is responsible for acute and postinfectious complications, including rheumatic fever and rheumatic heart disease (RHD). RHD is a global health burden, and Australia's indigenous population has one of the highest incidences of RHD worldwide. A potential peptide (J14) vaccine candidate has been previously identified from the C-terminal region of the M protein. However, such peptide-based vaccine development is hampered by a lack of carriers and adjuvants suitable for humans use. We have developed a fully synthetic peptide subunit vaccine candidate based on polyacrylate dendritic polymer. Intranasal administration of this nanoparticulate construct without additional adjuvant induced J14-specific IgG, which was also capable of in vitro opsonization of GAS, highlighting the potential of self-adjuvanting polyacrylate nanoparticle-based construct as a peptide vaccine delivery platform that may afford promising opportunities for treating systemic GAS infection.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.nano.2010.10.002
Volume 7
Issue Number 2
Page from 168
Page to 173
ISSN 1549-9634
Date Accessioned 2011-07-14
Date Available 2013-09-25T22:43:25Z
Language en_US
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Biological Sciences
URI http://hdl.handle.net/10072/39994
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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