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dc.contributor.authorBerners-Price, Susan J
dc.contributor.authorFilipovska, Aleksandra
dc.date.accessioned2017-09-25T22:14:40Z
dc.date.available2017-09-25T22:14:40Z
dc.date.issued2008
dc.date.modified2011-08-12T06:22:20Z
dc.identifier.issn0004-9425
dc.identifier.doi10.1071/CH08175
dc.identifier.urihttp://hdl.handle.net/10072/39996
dc.description.abstractRecent developments in understanding the central place of mitochondria as regulators of programmed cell death have stimulated enormous interest in using them as targets for cancer chemotherapy. To overcome drug resistance and the lack of selectivity of cancer drugs in differentiating between normal and tumour cells, many strategies have been described in recent literature, including the use of delocalized lipophilic cations that selectively accumulate in tumour-cell mitochondria. Thioredoxin reductase, an enzyme involved in redox regulation and cell growth, has also emerged recently as an attractive drug target. Here we discuss the rationale for the design of lipophilic, cationic Au(i) phosphine complexes that are targeted to mitochondria of tumour cells and have potent and selective anticancer activity for cancer cells but not for normal cells. Our discovery that the thioredoxin system may be a critical target responsible for the selective toxicity provides a new strategy in the development of mitochondria-targeted chemotherapeutics.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCSIRO Publishing
dc.publisher.placeAustralia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom661
dc.relation.ispartofpageto668
dc.relation.ispartofissue9
dc.relation.ispartofjournalAustralian Journal of Chemistry
dc.relation.ispartofvolume61
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchInorganic chemistry not elsewhere classified
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340299
dc.titleThe Design of Gold-Based, Mitochondria-Targeted Chemotherapeutics
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorBerners-Price, Sue J.


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