The Design of Gold-Based, Mitochondria-Targeted Chemotherapeutics

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Title The Design of Gold-Based, Mitochondria-Targeted Chemotherapeutics
Author Berners-Price, Sue; Filipovska, Aleksandra
Journal Name Australian Journal of Chemistry
Year Published 2008
Place of publication Australia
Publisher CSIRO Publishing
Abstract Recent developments in understanding the central place of mitochondria as regulators of programmed cell death have stimulated enormous interest in using them as targets for cancer chemotherapy. To overcome drug resistance and the lack of selectivity of cancer drugs in differentiating between normal and tumour cells, many strategies have been described in recent literature, including the use of delocalized lipophilic cations that selectively accumulate in tumour-cell mitochondria. Thioredoxin reductase, an enzyme involved in redox regulation and cell growth, has also emerged recently as an attractive drug target. Here we discuss the rationale for the design of lipophilic, cationic Au(i) phosphine complexes that are targeted to mitochondria of tumour cells and have potent and selective anticancer activity for cancer cells but not for normal cells. Our discovery that the thioredoxin system may be a critical target responsible for the selective toxicity provides a new strategy in the development of mitochondria-targeted chemotherapeutics.
Peer Reviewed Yes
Published Yes
Alternative URI
Volume 61
Issue Number 9
Page from 661
Page to 668
ISSN 0004-9425
Date Accessioned 2011-07-15
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Inorganic Chemistry
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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