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dc.contributor.authorHerd, Karen A
dc.contributor.authorNelson, Michelle
dc.contributor.authorMahalingam, Suresh
dc.contributor.authorTindle, Robert W
dc.date.accessioned2017-05-03T14:55:03Z
dc.date.available2017-05-03T14:55:03Z
dc.date.issued2010
dc.date.modified2011-08-12T06:22:21Z
dc.identifier.issn0022-1317
dc.identifier.doi10.1099/vir.0.015396-0
dc.identifier.urihttp://hdl.handle.net/10072/39997
dc.description.abstractHuman metapneumovirus (hMPV) is a major cause of upper and lower respiratory-tract infection in infants, the elderly and immunocompromised individuals. Virus-directed cellular immunity elicited by hMPV infection is poorly understood, in contrast to the phylogenetically and clinically related pathogen human respiratory syncytial virus (hRSV). In a murine model of acute lower respiratory-tract infection with hMPV, we demonstrate the accumulation of gamma interferon (IFN-?)-producing CD8+ T cells in the airways and lungs at day 7 post-infection (p.i.), associated with cytotoxic T lymphocytes (CTLs) directed to an epitope of the M2-1 protein. This CTL immunity was accompanied by increased pulmonary expression of Th1 cytokines IFN-? and interleukin (IL)-12 and antiviral cytokines (IFN-ߩ, as well as chemokines Mip-1a, Mip-1߬ Mig, IP-10 and CX3CL1. There was also a moderate increase in Th2-type cytokines IL-4 and IL-10 compared with uninfected mice. At 21 days p.i., a strong CTL response could be recalled from the spleen. A similar pattern of CTL induction to the homologous M2-1 CTL epitope of hRSV, and of cytokine/chemokine induction, was observed following infection with hRSV, highlighting similarities in the cellular immune response to the two related pathogens.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSociety for General Microbiology
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1302
dc.relation.ispartofpageto1310
dc.relation.ispartofissue5
dc.relation.ispartofjournalJournal of General Virology
dc.relation.ispartofvolume91
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310799
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode32
dc.titlePulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorMahalingam, Suresh


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