Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus

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Title Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus
Author Herd, Karen A.; Nelson, Michelle; Mahalingam, Suresh; Tindle, Robert W.
Journal Name Journal of General Virology
Year Published 2010
Place of publication United Kingdom
Publisher Society for General Microbiology
Abstract Human metapneumovirus (hMPV) is a major cause of upper and lower respiratory-tract infection in infants, the elderly and immunocompromised individuals. Virus-directed cellular immunity elicited by hMPV infection is poorly understood, in contrast to the phylogenetically and clinically related pathogen human respiratory syncytial virus (hRSV). In a murine model of acute lower respiratory-tract infection with hMPV, we demonstrate the accumulation of gamma interferon (IFN-γ)-producing CD8+ T cells in the airways and lungs at day 7 post-infection (p.i.), associated with cytotoxic T lymphocytes (CTLs) directed to an epitope of the M2-1 protein. This CTL immunity was accompanied by increased pulmonary expression of Th1 cytokines IFN-γ and interleukin (IL)-12 and antiviral cytokines (IFN-β), as well as chemokines Mip-1α, Mip-1β, Mig, IP-10 and CX3CL1. There was also a moderate increase in Th2-type cytokines IL-4 and IL-10 compared with uninfected mice. At 21 days p.i., a strong CTL response could be recalled from the spleen. A similar pattern of CTL induction to the homologous M2-1 CTL epitope of hRSV, and of cytokine/chemokine induction, was observed following infection with hRSV, highlighting similarities in the cellular immune response to the two related pathogens.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1099/vir.0.015396-0
Volume 91
Issue Number 5
Page from 1302
Page to 1310
ISSN 0022-1317
Date Accessioned 2011-07-15
Date Available 2011-08-12T06:22:21Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Microbiology
URI http://hdl.handle.net/10072/39997
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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