dc.contributor.author | Herd, Karen A | |
dc.contributor.author | Nelson, Michelle | |
dc.contributor.author | Mahalingam, Suresh | |
dc.contributor.author | Tindle, Robert W | |
dc.date.accessioned | 2017-05-03T14:55:03Z | |
dc.date.available | 2017-05-03T14:55:03Z | |
dc.date.issued | 2010 | |
dc.date.modified | 2011-08-12T06:22:21Z | |
dc.identifier.issn | 0022-1317 | |
dc.identifier.doi | 10.1099/vir.0.015396-0 | |
dc.identifier.uri | http://hdl.handle.net/10072/39997 | |
dc.description.abstract | Human metapneumovirus (hMPV) is a major cause of upper and lower respiratory-tract infection in infants, the elderly and immunocompromised individuals. Virus-directed cellular immunity elicited by hMPV infection is poorly understood, in contrast to the phylogenetically and clinically related pathogen human respiratory syncytial virus (hRSV). In a murine model of acute lower respiratory-tract infection with hMPV, we demonstrate the accumulation of gamma interferon (IFN-?)-producing CD8+ T cells in the airways and lungs at day 7 post-infection (p.i.), associated with cytotoxic T lymphocytes (CTLs) directed to an epitope of the M2-1 protein. This CTL immunity was accompanied by increased pulmonary expression of Th1 cytokines IFN-? and interleukin (IL)-12 and antiviral cytokines (IFN-ߩ, as well as chemokines Mip-1a, Mip-1߬ Mig, IP-10 and CX3CL1. There was also a moderate increase in Th2-type cytokines IL-4 and IL-10 compared with uninfected mice. At 21 days p.i., a strong CTL response could be recalled from the spleen. A similar pattern of CTL induction to the homologous M2-1 CTL epitope of hRSV, and of cytokine/chemokine induction, was observed following infection with hRSV, highlighting similarities in the cellular immune response to the two related pathogens. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Society for General Microbiology | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1302 | |
dc.relation.ispartofpageto | 1310 | |
dc.relation.ispartofissue | 5 | |
dc.relation.ispartofjournal | Journal of General Virology | |
dc.relation.ispartofvolume | 91 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Microbiology not elsewhere classified | |
dc.subject.fieldofresearch | Agricultural, veterinary and food sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 310799 | |
dc.subject.fieldofresearchcode | 30 | |
dc.subject.fieldofresearchcode | 32 | |
dc.title | Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2010 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Mahalingam, Suresh | |