Placental Oxidative Stress, Selenium and Preeclampsia

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Title Placental Oxidative Stress, Selenium and Preeclampsia
Author Perkins, Anthony Vincent
Journal Name Pregnancy Hypertension
Year Published 2011
Place of publication United Kingdom
Publisher Elsevier
Abstract There is considerable evidence that placental oxidative stress plays a significant role in the etiology of preeclampsia. Prophylactic use of exogenous anti-oxidants such as vitamins E and C have proven to be ineffective and potentially dangerous. The current study addresses the role of endogenous anti-oxidant systems in preeclampsia. In particular, data on the selenodependent enzymes glutathione peroxidase and thioredoxin reductase will be presented and the role of selenium in preeclampsia will be considered. The aim of these studies was to determine the levels of endogenous antioxidants, selenium, and biological oxidation in normal and preeclamptic placental tissues. Furthermore, animal studies were conducted to assess the impact of selenium depletion on anti-oxidant expression and activity, oxidative stress and symptoms of preeclampsia. Selenium depletion generated placental oxidative stress and produced a preeclamptic like syndrome in pregnant rats suggesting a link between placental oxidative stress, endogenous antioxidant disequilibria and the pathogenesis of preeclampsia that may be linked to insufficient dietary selenium. The selenium of status of preeclamptic mothers was also considered and lower levels of selenium were observed when compared to normal controls. Selenium supplementation improves endogenous anti-oxidant expression in trophoblast cells and might provide an effective method of protecting the placenta from oxidative stress during preeclampsia. Clinical studies are now underway to investigate the benefits of low dose selenium supplementation on the development and progression of preeclampsia.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.preghy.2010.10.008
Volume 1
Issue Number 1
Page from 95
Page to 99
ISSN 2210-7789
Date Accessioned 2011-03-10
Language en_AU
Research Centre Griffith Health Institute
Faculty Griffith Health Faculty
Subject Obstetrics and Gynaecology; PRE2009-Biochemistry and Cell Biology
URI http://hdl.handle.net/10072/40113
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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