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dc.contributor.authorA. Cunningham, Kelly
dc.contributor.authorJ. Carey, Alison
dc.contributor.authorM. Finnie, Jane
dc.contributor.authorBao, Shisan
dc.contributor.authorCoon, Charmere
dc.contributor.authorJones, Russell
dc.contributor.authorWijburg, Odilia
dc.contributor.authorA. Strugnell, Richard
dc.contributor.authorTimms, Peter
dc.contributor.authorW. Beagley, Kenneth
dc.date.accessioned2017-05-03T15:53:04Z
dc.date.available2017-05-03T15:53:04Z
dc.date.issued2008
dc.date.modified2011-08-19T06:43:52Z
dc.identifier.issn16000897
dc.identifier.doi10.1111/j.1600-0897.2008.00637.x
dc.identifier.urihttp://hdl.handle.net/10072/40124
dc.description.abstractProblem Chlamydia trachomatis is the most common sexually transmitted infection worldwide. While infection in females requires a Th1 response for clearance, such a response in males may disrupt the immune privileged nature of the male reproductive tract, potentially contributing to infertility. Method of study We investigated the role of IgA in protection against an intrapenile Chlamydia muridarum infection of C57BL / 6 and pIgR) / ) mice. Results Here, we show that the poly immunoglobulin receptor is the main pathway for IgA transport into the male reproductive tract. The high levels of IgA seen in prostatic fluid of wild-type mice correlate with reduction in chlamydial infection both in vitro and in vivo. Conclusion These findings indicate that a Chlamydia vaccine that induces neutralizing IgA in the prostate will aid in the protection against infection in males.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc.
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom405
dc.relation.ispartofpageto414
dc.relation.ispartofissue5
dc.relation.ispartofjournalAmerican Journal of Reproductive Immunology
dc.relation.ispartofvolume60
dc.rights.retentionY
dc.subject.fieldofresearchHumoural Immunology and Immunochemistry
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchcode110705
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1107
dc.subject.fieldofresearchcode1114
dc.titlePoly-Immunoglobulin Receptor-Mediated Transport of IgA into the Male Genital Tract is Important for Clearance of Chlamydia muridarum Infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorCarey, Alison


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