Knee biomechanics during walking gait following matrix-induced autologous chondrocyte implantation

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Title Knee biomechanics during walking gait following matrix-induced autologous chondrocyte implantation
Author Ebert, Jay R.; Lloyd, David Gavin; Ackland, Timothy; Wood, David J.
Journal Name Clinical Biomechanics
Year Published 2010
Place of publication United Kingdom
Publisher Elsevier
Abstract Background Matrix-induced autologous chondrocyte implantation is a technique for repairing articular cartilage defects in the knee. Despite reported improvements in pain, little is known about the recovery of knee biomechanics during walking gait. Methods A randomized controlled study design was used to investigate knee biomechanics during gait in 61 patients following matrix-induced autologous chondrocyte implantation, in conjunction with either 'accelerated' or 'traditional' approaches to post-operative weight-bearing rehabilitation. Gait analysis was performed at 3, 6 and 12 months post-surgery in both patient groups, and two matched, unaffected control groups for comparison. Findings The spatiotemporal and ground reaction force parameters were similar between patient groups and their respective control groups at all time points. When compared with controls, both patient groups demonstrated significantly reduced knee extension moments up until, and including, 12 months. The traditional group demonstrated a significantly reduced knee adduction moment at 3, 6 and 12 months, and a significantly reduced knee flexion moment at 3 months. There were no differences in these knee moments between the accelerated patient group and controls. Interpretation Overall, a higher level of gait dysfunction was observed in patients who underwent traditional rehabilitation. Future research is needed to investigate the recovery of normal gait following matrix-induced autologous chondrocyte implantation, and its effect on repair tissue development.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.clinbiomech.2010.07.004
Volume 25
Issue Number 10
Page from 1011
Page to 1017
ISSN 0268-0033
Date Accessioned 2011-07-21
Date Available 2011-08-19T06:44:34Z
Language en_AU
Research Centre Centre for Musculoskeletal Research
Faculty Griffith Health Faculty
Subject Biomechanics
URI http://hdl.handle.net/10072/40141
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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