The effects of polyphenols in olive leaves on platelet function

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Title The effects of polyphenols in olive leaves on platelet function
Author Singh, Indu; Mok, Michelle; Christensen, Anne-Marie; Turner, Alan H.; Hawley, John A.
Journal Name Nutrition, Metabolism & Cardiovascular Diseases
Year Published 2008
Place of publication United Kingdom
Publisher Elsevier Ltd.
Abstract Introduction The phenolic compounds of olive leaves and olive oils in the Mediterranean diet have been associated with a reduced incidence of heart disease. Accordingly, antioxidant-rich diets may prevent the deleterious effects of oxidative metabolism by scavenging free radicals, thus inhibiting oxidation and delaying atherosclerosis. The process involves phospholipase C activation and arachidonic acid metabolism, and is thought to reduce hydrogen peroxide (H2O2). In our study, an extract of Olea europaea L. leaves was used. The active phenolic compounds in this extract are part of the secoiridoid family, known for their capacity to scavenge H2O2. The results from this study will help to improve our understanding of effects of polyphenol antioxidants in olive leaf extract on platelet function. Methods Full blood examination (FBE), platelet aggregation, and ATP release were performed on samples from fasting, normal, healthy male subjects. Platelet function at increasing concentrations of oleuropein was investigated through measures of platelet aggregation and ATP release from activated platelets. Results Blood analysis (n = 11) revealed a significant dose-dependant reduction in platelet activity with olive extract concentrations of 1.0% v/v (P < 0.001). ATP Release showed a similar pattern (P = 0.02). Conclusions Olive leaf polyphenols derived from O. europaea L. leaves inhibited in vitro platelet activation in healthy, non-smoking males. Further bioavailability studies need to be undertaken to determine the in vivo effect of extract on platelet function and to validate the present results.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.numecd.2006.09.001
Copyright Statement Copyright 2008 Elsevier Inc. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 18
Issue Number 2
Page from 127
Page to 132
ISSN 0939-4753
Date Accessioned 2011-06-16
Language en_AU
Research Centre Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject Cardiovascular Medicine and Haematology
URI http://hdl.handle.net/10072/40269
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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