Development of a Liposaccharide-Based Delivery System and Its Application to the Design of Group A Streptococcal Vaccines

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Title Development of a Liposaccharide-Based Delivery System and Its Application to the Design of Group A Streptococcal Vaccines
Author Simerska, Pavla; Abdel-Aal, Abu-Baker M.; Fujita, Yoshio; Moyle, Peter M.; McGeary, Ross P.; Batzloff, Michael Raymond; Olive, Colleen; Good, Michael Francis; Toth, Istvan
Journal Name Journal of Medicinal Chemistry
Year Published 2008
Place of publication United States
Publisher American Chemical Society
Abstract Group A streptococcus (GAS) is associated with many human diseases, ranging in severity from benign to life-threatening. A promising strategy for developing vaccines against GAS involves the use of carbohydrates as carriers for peptide antigens. This study describes the optimized synthesis of d-glucose and d-galactose derived carriers, bearing an adipate linker and four tert-butoxycarbonyl protected aminopropyl groups. Prophylactic GAS vaccine candidates were synthesized by conjugating multiple copies of a single GAS M protein derived peptide antigen (either J8 or J14) onto the carbohydrate carriers. These antigens contain peptide sequences, which are highly conserved and offer the potential to prevent infections caused by up to 70% of GAS strains. Lipophilic amino acids were also conjugated to the d-glucose anomeric carbon to produce a self-adjuvanting liposaccharide vaccine. High serum IgG antibody titers against each of the incorporated peptide epitopes were detected following subcutaneous immunization of B10.BR (H-2k) mice with the liposaccharide vaccine candidates.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1021/jm701410p
Copyright Statement Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Volume 51
Issue Number 5
Page from 1447
Page to 1452
ISSN 0022-2623
Date Accessioned 2011-03-21
Date Available 2014-01-08T04:56:04Z
Language en_US
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Agents
URI http://hdl.handle.net/10072/40446
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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