Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst
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| 69237_1.pdf | 132Kb | Adobe PDF | View |
| Title | Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst |
|---|---|
| Author | El-Deeb, Ibrahim Mustafa; Ryu, Jae Chun; Lee, So Ha |
| Journal Name | Molecules |
| Year Published | 2008 |
| Place of publication | Switzerland |
| Publisher | MDPIAG |
| Abstract | New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesizedfrom the corresponding amines, applying optimized Buchwald-Hartwig aminationconditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tertbutoxidein refluxing toluene under a nitrogen atmosphere. The target N-aryl derivativeswere obtained in moderate to good yields ranging from 27% to 82%. The proceduredescribed could be widely employed for the preparation of new heterocyclic compounds.The structures of the new compounds were confirmed by FT-NMR, FT-IR and elementalanalysis. |
| Peer Reviewed | Yes |
| Published | Yes |
| Alternative URI | http://dx.doi.org/10.3390/molecules13040818 |
| Copyright Statement | Copyright 2008 MDPI (http://www.mdpi.org). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version. |
| Volume | 13 |
| Issue Number | 4 |
| Page from | 818 |
| Page to | 830 |
| ISSN | 1420-3049 |
| Date Accessioned | 2011-03-18 |
| Date Available | 2011-10-21T07:24:56Z |
| Language | en_AU |
| Research Centre | Institute for Glycomics |
| Faculty | Faculty of Science, Environment, Engineering and Technology |
| Subject | Organic Chemical Synthesis |
| URI | http://hdl.handle.net/10072/40488 |
| Publication Type | Journal Articles (Refereed Article) |
| Publication Type Code | c1x |
Please use this identifier to cite this record: http://hdl.handle.net/10072/40488
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