Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst

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Title Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst
Author El-Deeb, Ibrahim Mustafa; Ryu, Jae Chun; Lee, So Ha
Journal Name Molecules
Year Published 2008
Place of publication Switzerland
Publisher MDPIAG
Abstract New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesizedfrom the corresponding amines, applying optimized Buchwald-Hartwig aminationconditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tertbutoxidein refluxing toluene under a nitrogen atmosphere. The target N-aryl derivativeswere obtained in moderate to good yields ranging from 27% to 82%. The proceduredescribed could be widely employed for the preparation of new heterocyclic compounds.The structures of the new compounds were confirmed by FT-NMR, FT-IR and elementalanalysis.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.3390/molecules13040818
Copyright Statement Copyright 2008 MDPI (http://www.mdpi.org). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 13
Issue Number 4
Page from 818
Page to 830
ISSN 1420-3049
Date Accessioned 2011-03-18
Date Available 2011-10-21T07:24:56Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Organic Chemical Synthesis
URI http://hdl.handle.net/10072/40488
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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