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dc.contributor.authorBattle, Andrew R
dc.contributor.authorValenzuela, Stella M
dc.contributor.authorMechler, Adam
dc.contributor.authorNichols, Ryan J
dc.contributor.authorPraporski, Slavica
dc.contributor.authordi Maio, Isabelle L
dc.contributor.authorIslam, Hedoyetul
dc.contributor.authorCirard-Egrot, Agnes P
dc.contributor.authorCornell, Bruce A
dc.contributor.authorPrashar, Jog
dc.contributor.authorCaruso, Frank
dc.contributor.authorMartin, Lisandra L
dc.contributor.authorMartin, Donald K
dc.date.accessioned2017-05-03T16:04:29Z
dc.date.available2017-05-03T16:04:29Z
dc.date.issued2009
dc.date.modified2011-08-31T07:18:37Z
dc.identifier.issn1616-301X
dc.identifier.doi10.1002/adfm.200800483
dc.identifier.urihttp://hdl.handle.net/10072/40531
dc.description.abstractThe development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of "smart" biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom201
dc.relation.ispartofpageto208
dc.relation.ispartofissue2
dc.relation.ispartofjournalAdvanced Functional Materials
dc.relation.ispartofvolume19
dc.rights.retentionY
dc.subject.fieldofresearchPhysical sciences
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode51
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode40
dc.titleNovel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorBattle, Andrew


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