dc.contributor.author | Battle, Andrew R | |
dc.contributor.author | Valenzuela, Stella M | |
dc.contributor.author | Mechler, Adam | |
dc.contributor.author | Nichols, Ryan J | |
dc.contributor.author | Praporski, Slavica | |
dc.contributor.author | di Maio, Isabelle L | |
dc.contributor.author | Islam, Hedoyetul | |
dc.contributor.author | Cirard-Egrot, Agnes P | |
dc.contributor.author | Cornell, Bruce A | |
dc.contributor.author | Prashar, Jog | |
dc.contributor.author | Caruso, Frank | |
dc.contributor.author | Martin, Lisandra L | |
dc.contributor.author | Martin, Donald K | |
dc.date.accessioned | 2017-05-03T16:04:29Z | |
dc.date.available | 2017-05-03T16:04:29Z | |
dc.date.issued | 2009 | |
dc.date.modified | 2011-08-31T07:18:37Z | |
dc.identifier.issn | 1616-301X | |
dc.identifier.doi | 10.1002/adfm.200800483 | |
dc.identifier.uri | http://hdl.handle.net/10072/40531 | |
dc.description.abstract | The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of "smart" biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley - V C H Verlag GmbH & Co. KGaA | |
dc.publisher.place | Germany | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 201 | |
dc.relation.ispartofpageto | 208 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Advanced Functional Materials | |
dc.relation.ispartofvolume | 19 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Physical sciences | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Engineering | |
dc.subject.fieldofresearchcode | 51 | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 40 | |
dc.title | Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2009 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Battle, Andrew | |