Placental Malaria-Associated Inflammation Disturbs the Insulin-like Growth Factor Axis of Fetal Growth Regulation

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Title Placental Malaria-Associated Inflammation Disturbs the Insulin-like Growth Factor Axis of Fetal Growth Regulation
Author Umbers, Alexandra J.; Boeuf, Philippe; Clapham, Caroline; Stanisic, Danielle; Baiwog, Francesca; Mueller, Ivo; Siba, Peter; King, Christopher L.; Beeson, James G.; Glazier, Jocelyn; Rogerson, Stephen J.
Journal Name Journal of Infectious Diseases
Year Published 2011
Place of publication United States
Publisher Oxford University Press
Abstract Background. The pathogenetic mechanisms of fetal growth restriction associated with placental malaria are largely unknown. We sought to determine whether placental malaria and related inflammation were associated with disturbances in the insulin-like growth factor (IGF) axis, a major regulator of fetal growth. Method. We measured IGF-1 and IGF-2 concentrations in plasma from 88 mother-neonate pairs at delivery and IGF binding proteins 1 and 3 (IGFBP-1 and IGFBP-3, respectively) in cord plasma from a cohort of Papua New Guinean women with and without placental malaria. Messenger RNA levels of IGF-1, IGF-2, and the IGF receptors were measured in matched placental biopsy specimens. Results. Compared with those for uninfected pregnancies, IGF-1 levels were reduced by 28% in plasma samples from women with placental Plasmodium falciparum infection and associated inflammation (P = .007) and by 25% in their neonates (P = .002). Levels of fetal IGFBP-1 were elevated in placental malaria with and without inflammation (P = .08 and P = .006, respectively) compared with uninfected controls. IGF-2 and IGFBP-3 plasma concentrations and placental IGF ligand and receptor messenger RNA transcript levels were similar across groups. Conclusion. Placental malaria-associated inflammation disturbs maternal and fetal levels of IGFs, which regulate fetal growth. This may be one mechanism by which placental malaria leads to fetal growth restriction.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1093/infdis/jiq080
Copyright Statement Copyright 2011 by University of Chicago Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. First published in The Journal of Geology. Please refer to the journal's website for access to the definitive, published version.
Volume 203
Issue Number 4
Page from 561
Page to 569
ISSN 0022-1899
Date Accessioned 2011-03-22
Language en_US
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Immunology
URI http://hdl.handle.net/10072/40889
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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