Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment

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Title Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment
Author Waugh, Courtney A.; Huston, Wilhelmina M.; Noad, Michael J.; Bengtson Nash, Susan
Journal Name Marine Pollution Bulletin
Year Published 2011
Place of publication United Kingdom
Publisher Elsevier
Abstract Large mysticete whales represent a unique challenge for chemical risk assessment. Few epidemiological investigations are possible due to the low incidence of adult stranding events. Similarly their often extreme life-history adaptations of prolonged migration and fasting challenge exposure assumptions. Molecular biomarkers offer the potential to complement information yielded through tissue chemical analysis, as well as providing evidence of a molecular response to chemical exposure. In this study we confirm the presence of cytochrome P450 reductase (CPR) and cytochrome P450 isoenzyme 1A1 (CYP1A1) in epidermal tissue of southern hemisphere humpback whales (Megaptera novaeangliae). The detection of CYP1A1 in the integument of the humpback whale affords the opportunity for further quantitative non-destructive investigations of enzyme activity as a function of chemical stress.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.marpolbul.2011.01.007
Volume 62
Issue Number 4
Page from 758
Page to 761
ISSN 0025-326X
Date Accessioned 2011-06-08
Date Available 2011-09-22T06:50:11Z
Language en_AU
Research Centre Environmental Futures Research Institute
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Environmental Science and Management
URI http://hdl.handle.net/10072/40912
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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