Myocardial Opioid Receptors in Conditioning and Cytoprotection

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Title Myocardial Opioid Receptors in Conditioning and Cytoprotection
Author Williams-Pritchard, Grant; Headrick, John Patrick; Peart, Jason Nigel John
Journal Name Pharmaceuticals
Year Published 2011
Place of publication Switzerland
Publisher MDPIAG
Abstract Abstract: Opioid compounds and G-protein coupled opioid receptors (ORs) have been studied widely in terms of central nervous system (CNS) actions relating to pain management and drug abuse. Opioids are also linked to induction of mammalian hibernation, a natural state of tolerance involving prolonged and orchestrated shifts in cellular metabolism, growth and stress resistance. It is not surprising then that OR agonism induces acute or delayed cytoprotective states in myocardium, rendering ORs an attractive target for protection of cardiac tissue from the potentially fatal consequences of ischemic heart disease. Cardiac ORs are implicated in triggering/mediating so-called 'conditioning' responses, in which powerful cytoprotection arises following transient receptor ligation prior to or immediately following ischemic insult. These responses involve one or more OR sub-types engaging pro-survival kinase cascades to ultimately modulate cell stress and mitochondrial end-effectors. However, important questions remain regarding the role of endogenous opioids, OR signalling, and the transduction and mediation of these protective responses. We briefly review opioid-mediated cardioprotection, focussing on recent developments in signal transduction, the role of receptor 'cross-talk', and the effects of sustained OR ligand activation.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.3390/ph4030470
Copyright Statement Copyright 2011 MDPI (http://www.mdpi.org). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 4
Issue Number 3
Page from 470
Page to 484
ISSN 1424-8247
Date Accessioned 2011-07-22
Date Available 2011-10-07T04:28:35Z
Language en_AU
Research Centre Griffith Health Institute; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject Systems Physiology
URI http://hdl.handle.net/10072/41181
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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