Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

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Title Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
Author Kote-Jarai, Zsofia; Olama, Ali Amin Al; Giles, Graham; Severi, Gianluca; Schleutker, Johanna; Weischer, Maren; Canzian, Federico; Riboli, Elio; Key, Tim; Gronberg, Henrik; Hunter, David; Kraft, Peter; Thun, Michael J; Ingles, Sue A; Channock, Stephen; Albanes, Demetrius; Hayes, Richard B; Neal, David; Hamdy, Freddie C; Donovan, Jenny L; Pharoah, Paul; Schumacher, Fredrick; Henderson, Brian E; Stanford, Janet L; Ostrander, Elaine A; Sorensen, Karina Dalsgaard; Dork, Thilo; Andriole, Gerald; Dickinson, Joanne L; et al.; Chambers, Suzanne Kathleen
Journal Name Nature Genetics
Year Published 2011
Place of publication United States
Publisher Nature Publishing Group
Abstract Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10−8 to P = 2.7 × 10−24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1038/ng.882
Volume 43
Issue Number 8
Page from 785
Page to 791
ISSN 1061-4036
Date Accessioned 2011-07-21
Date Available 2013-09-01T23:54:59Z
Language en_US
Research Centre Centre for Health Practice Innovation; Behavioural Basis of Health
Faculty Griffith Health Faculty
Subject Cancer Genetics
URI http://hdl.handle.net/10072/41202
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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