Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro

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Title Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro
Author Beattie, Karren; Ulrich, Rahel; Grice, Darren; Uddin, Shaikh Jamal; Blake, Tony; Wood, Kyle Andrew; Steele, Jules; Iu, Fontaine; May, Tom W.; Tiralongo, Evelin
Journal Name Mycologia
Year Published 2011
Place of publication United States
Publisher Mycological Society of America
Abstract Fifteen Australian macrofungi were investigated for cytotoxic activity. Ethanol, cold and hot water extracts of each species were screened for cytotoxic activity against normal mouse fibroblast cells (NIH/3T3), healthy human epithelial kidney cells (HEK-293), four cancer cell lines, gastric adenocarcinoma cells (AGS), two mammary gland adenocarcinoma cells (MDA-MB-231, MCF7) and colorectal adenocarcinoma cells (HT-29) with a validated MTT assay. Most extracts derived from Omphalotus nidiformis, Cordyceps cranstounii and Cordyceps gunnii demonstrated significant cytotoxic activity toward a variety of cancer cell lines. In contrast only some extracts from Coprinus comatus, Cordyceps hawkesii, Hypholoma fasciculare, Lepista nuda, Leratiomyces ceres and Ophiocordyceps robertsii displayed significant cytotoxic activity, which was usually selective for only one or two cancer cell lines tested. The least cytotoxic species evaluated in this study were Agaricus bitorquis, Coprinopsis atrametaria, Psathyrella asperospora, Russula clelandii, Tricholoma sp. AU2 and Xerula mundroola.
Peer Reviewed Yes
Published Yes
Alternative URI
Volume 103
Issue Number 3
Page from 458
Page to 465
ISSN 0027-5514
Date Accessioned 2011-06-12
Language en_AU
Research Centre Menzies Health Institute Qld; Institute for Glycomics; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Complementary and Alternative Medicine; Pharmacology and Pharmaceutical Sciences
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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