DNA amplification approaches for the diagnosis of key parasitic helminth infections of humans

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Title DNA amplification approaches for the diagnosis of key parasitic helminth infections of humans
Author Gordon, Catherine A.; Gray, Darren; Gobert, Geoffrey N.; McManus, Donald P.
Journal Name Molecular and Cellular Probes
Year Published 2011
Place of publication United Kingdom
Publisher Elsevier
Abstract Parasitic helminths of humans are a major public health threat, particularly in developing countries. The rapid and reliable diagnosis of helminth infections is central to their control as well as for environmental monitoring and disease surveillance. Effective diagnosis is dependent on the sensitivity, specificity and reliability of the tests employed. The most commonly used diagnosis of helminth infections has been the microscopic detection of eggs in faecal samples. However, the eggs of related helminths are often very similar in morphology and morphometry, making diagnosis inaccurate. DNA amplification tests can provide alternative approaches for diagnosis and can be sensitive and specific, provided reliable molecular genetic markers are employed in the tests. Such advanced tools can be used for the quantification of egg numbers, in order to assess infection intensities in infected hosts, and can provide multiplexing capability which can be required for the identification of multiple different helminth species in individual samples. These approaches provide powerful diagnostic techniques that can be used in clinical settings and as laboratory tools for surveillance and for environmental monitoring to support helminth control programs.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.mcp.2011.05.002
Volume 25
Issue Number 4
Page from 143
Page to 152
ISSN 0890-8508
Date Accessioned 2011-06-24
Language en_AU
Faculty Griffith Health Faculty
Subject Medical Parasitology
URI http://hdl.handle.net/10072/41255
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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