Latifolians A and B, Novel JNK3 Kinase Inhibitors from the Papua New Guinean Plant Gnetum latifolium
Author(s)
Rochfort, SJ
Towerzey, L
Carroll, A
King, G
Michael, A
Pierens, G
Rali, T
Redburn, J
Whitmore, J
Quinn, RJ
Year published
2005
Metadata
Show full item recordAbstract
As part of our search for natural products active against the JNK3 kinase, two novel, charged benzylisoquinolines, latifolian A (1) and latifolian B (2), were isolated from the stem bark of the Papua New Guinean vine Gnetum latifolium. The planar structures were determined through detailed 2D NMR analysis. The relative configurations were assigned after examination of the ROESY data and through detailed molecular modeling studies.As part of our search for natural products active against the JNK3 kinase, two novel, charged benzylisoquinolines, latifolian A (1) and latifolian B (2), were isolated from the stem bark of the Papua New Guinean vine Gnetum latifolium. The planar structures were determined through detailed 2D NMR analysis. The relative configurations were assigned after examination of the ROESY data and through detailed molecular modeling studies.
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Journal Title
Journal of Natural Products
Volume
68
Issue
7
Publisher URI
Copyright Statement
© 2005 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please use the hypertext link above to access the journal's website or contact the author for more information.
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine