Show simple item record

dc.contributor.authorZobalova, Renata
dc.contributor.authorProkopova, Katerina
dc.contributor.authorStantic, Marina
dc.contributor.authorStapelberg, Michael
dc.contributor.authorDong, Lan-Feng
dc.contributor.authorRalph, Stephen J
dc.contributor.authorAkporiaye, Emmanuel
dc.contributor.authorNeuzil, Jiri
dc.date.accessioned2017-05-03T14:14:57Z
dc.date.available2017-05-03T14:14:57Z
dc.date.issued2011
dc.date.modified2012-02-10T03:57:01Z
dc.identifier.issn1523-0864
dc.identifier.doi10.1089/ars.2010.3785
dc.identifier.urihttp://hdl.handle.net/10072/41693
dc.description.abstractSignificance: Recent research has shown that tumors contain a small subpopulation of stem-like cells that are more resistant to therapy and that are likely to produce second-line tumors. Recent Advances: Cancer stem-like cells (CSCs) have been characterized by a variety of markers, including, for a number of types of cancer, high expression of the plasma membrane protein CD133, which is also indicative of the increase of stemness of cultured cancer cells growing as spheres. Critical Issues: While the function of this protein has not yet been clearly defined, it may have a role in the stem-like phenotype of CSCs that cause (re-)initiation of tumors as well as their propagation. We hypothesize that CD133 selects for CSC survival against not only immunosurveillance mechanisms but also stress-induced apoptosis. Future Directions: High level of expression of CD133 may be a useful marker of more aggressive tumors that are recalcitrant toward established therapies. Compelling preliminary data indicate that drugs targeting mitochondria may be utilized as a novel, efficient cancer therapeutic modality.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc. Publishers
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2989
dc.relation.ispartofpageto3002
dc.relation.ispartofissue12
dc.relation.ispartofjournalAntioxidants & Redox Signaling
dc.relation.ispartofvolume15
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical biochemistry and metabolomics
dc.subject.fieldofresearchCancer cell biology
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3205
dc.subject.fieldofresearchcode321101
dc.subject.fieldofresearchcode3214
dc.titleThe Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri
gro.griffith.authorRalph, Stephen J.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record