Isolation and Expression of a Novel Molecular Class D ß-lactamase, OXA-61, from Campylobacter jejuni.
Author(s)
Alfredson, DA
Korolik, V
Griffith University Author(s)
Year published
2005
Metadata
Show full item recordAbstract
A novel ߭lactamase gene, blaOXA-61, from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. blaOXA-61 encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D ߭lactamase motifs YGN and KTG were identified. A conserved sequence upstream of blaOXA-61 is required for expression in Campylobacter.A novel ߭lactamase gene, blaOXA-61, from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. blaOXA-61 encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D ߭lactamase motifs YGN and KTG were identified. A conserved sequence upstream of blaOXA-61 is required for expression in Campylobacter.
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Journal Title
Antimicrobial Agents and Chemotherapy
Volume
49
Issue
6
Subject
Microbiology
Medical microbiology
Pharmacology and pharmaceutical sciences