Crystallisation and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8

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Title Crystallisation and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8
Author Scott, Stacy; Holloway, Gavan; Coulson, Barbara S.; Szyczew, Alexander Jeffery; Kiefel, Milton; von Itzstein, Mark; Blanchard, Helen
Journal Name Acta Crystallographica Section F - Structural Biology and Crystallization Communications
Year Published 2005
Place of publication Oxford, England
Publisher Blackwell Publishing
Abstract Rotavirus recognition and attachment to host cells involves interaction with the spike protein VP4 that projects outwards from the surface of the virus particle. An integral component of these spikes is the VP8* domain, which is implicated in the direct recognition and binding of sialic acid-containing cell-surface carbohydrates and facilitates subsequent invasion by the virus. The expression, purification, crystallization and preliminary X-ray diffraction analysis of VP8* from porcine CRW-8 rotavirus is reported. Diffraction data have been collected to 2.3 Å resolution, enabling the determination of the VP8* structure by molecular replacement.
Peer Reviewed Yes
Published Yes
Publisher URI http://www3.interscience.wiley.com/journal/118719704/abstract?CRETRY=1&SRETRY=0
Alternative URI http://dx.doi.org/10.1107/S1744309105013849
Copyright Statement Copyright 2005 Blackwell Publishing. The definitive version is available at [www.blackwell-synergy.com.]
Volume F61
Issue Number 6
Page from 617
Page to 620
ISSN 1744-3091
Date Accessioned 2006-03-09
Date Available 2009-01-13T07:10:06Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Institute for Glycomics
Subject PRE2009-Biological and Medical Chemistry
URI http://hdl.handle.net/10072/4187
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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