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dc.contributor.authorVanderlelie, J
dc.contributor.authorPerkins, AVA
dc.date.accessioned2017-05-03T11:16:55Z
dc.date.available2017-05-03T11:16:55Z
dc.date.issued2011
dc.date.modified2012-07-22T22:48:26Z
dc.identifier.issn2210-7789
dc.identifier.doi10.1016/j.preghy.2011.07.001
dc.identifier.urihttp://hdl.handle.net/10072/42341
dc.description.abstractPreeclampsia is a complex multisystem disorder of pregnancy where oxidative stress plays an important aetiological role. The role of selenium in the synthesis of endogenous antioxidants is well documented, and a significant reduction in selenium has been reported in preeclamptic women. The objective of this study was to map global selenium status and preeclampsia incidence. This study identified peer reviewed journal articles reporting national preeclampsia incidence (%) and matched these with reported values of selenium intake and plasma/serum selenium concentrations (姯L). Matched data were obtained for 45 regions, reporting 6456,570 births, spanning Europe, Asia, Australasia, Africa, North and South America. Increasing plasma selenium concentration was found to be correlated with a reduction in preeclampsia incidence (Pearson's r = -0.604, P < 0.0001). Countries with a reported serum/plasma selenium level of ?95 姯L were considered selenium sufficient and a significant reduction in preeclampsia incidence for countries above this value (P = 0.0007) was noted. Significant reductions in preeclampsia incidence were found to coincide with increases in plasma/serum selenium concentration in the New Zealand (P = 0.0003) and Finland (0.0028) populations following Government intervention. This study supports the hypothesis that selenium supplementation may be beneficial in reducing oxidative stress in women at risk of preeclampsia.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent547375 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom213
dc.relation.ispartofpageto224
dc.relation.ispartofissue3-4
dc.relation.ispartofjournalPregnancy Hypertension
dc.relation.ispartofvolume1
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchReproduction
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode321503
dc.titleSelenium and preeclampsia: A global perspective
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2011 Elsevier Inc. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorPerkins, Anthony V.
gro.griffith.authorVanderlelie, Jessica J.


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