Activating Platinum Anticancer Complexes with Visible Light

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Title Activating Platinum Anticancer Complexes with Visible Light
Author Berners-Price, Sue
Journal Name Angewandte Chemie International Edition
Year Published 2011
Place of publication Germany
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Abstract The next generation: Classical PtII anticancer compounds contain cis diam(m)ine ligands and are activated by ligand-substitution reactions. PtIV diam(m)ine diazido dihydroxo complexes are nontoxic to cells until activated by light. Replacement of the diam(m)ine ligands in a trans configuration by pyridine gives a complex that is potently cytotoxic when irradiated with visible light and which has potential as a photochemotherapeutic agent.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1002/anie.201004552
Volume 50
Issue Number 4
Page from 804
Page to 805
ISSN 1433-7851
Date Accessioned 2011-01-28; 2012-02-13T05:01:50Z
Date Available 2012-02-13T05:01:50Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Bioinorganic Chemistry
URI http://hdl.handle.net/10072/42441
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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