Activating Platinum Anticancer Complexes with Visible Light
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| Title | Activating Platinum Anticancer Complexes with Visible Light |
|---|---|
| Author | Berners-Price, Sue |
| Journal Name | Angewandte Chemie International Edition |
| Year Published | 2011 |
| Place of publication | Germany |
| Publisher | Wiley - V C H Verlag GmbH & Co. KGaA |
| Abstract | The next generation: Classical PtII anticancer compounds contain cis diam(m)ine ligands and are activated by ligand-substitution reactions. PtIV diam(m)ine diazido dihydroxo complexes are nontoxic to cells until activated by light. Replacement of the diam(m)ine ligands in a trans configuration by pyridine gives a complex that is potently cytotoxic when irradiated with visible light and which has potential as a photochemotherapeutic agent. |
| Peer Reviewed | Yes |
| Published | Yes |
| Alternative URI | http://dx.doi.org/10.1002/anie.201004552 |
| Volume | 50 |
| Issue Number | 4 |
| Page from | 804 |
| Page to | 805 |
| ISSN | 1433-7851 |
| Date Accessioned | 2011-01-28; 2012-02-13T05:01:50Z |
| Date Available | 2012-02-13T05:01:50Z |
| Research Centre | Institute for Glycomics |
| Faculty | Faculty of Science, Environment, Engineering and Technology |
| Subject | Bioinorganic Chemistry |
| URI | http://hdl.handle.net/10072/42441 |
| Publication Type | Journal Articles (Refereed Article) |
| Publication Type Code | c1 |
Please use this identifier to cite this record: http://hdl.handle.net/10072/42441
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