Recognition of the GM3 Ganglioside Glycan by Rhesus Rotavirus Particles

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Title Recognition of the GM3 Ganglioside Glycan by Rhesus Rotavirus Particles
Author Haselhorst, Thomas Erwin; Fiebig, Timm; Dyason, Jeffrey Clifford; Fleming, Fiona E.; Blanchard, Helen; Coulson, Barbara S.; von Itzstein, Mark
Journal Name Angewandte Chemie International Edition
Year Published 2011
Place of publication Germany
Publisher Wiley
Abstract Rotaviruses are a major cause of severe infantile gastroenteritis in humans and animals worldwide, producing a childhood mortality exceeding 650 000 annually.[1] Mapping host cell glycan–virus interactions to define a viral glycointeractome is invaluable in providing new directions for the discovery of novel broad-spectrum drugs and vaccines. In that context we have recently reported the first NMR-based structural analysis of the interaction of GD1a (1) and GM1 (2) ganglioside glycans with recombinantly expressed rotaviral surface lectin VP8* from two distinct rotavirus strains.[2]
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1002/anie.201004116
Volume 50
Issue Number 5
Page from 1055
Page to 1058
ISSN 0044-8249
Date Accessioned 2011-12-20; 2012-02-13T05:06:23Z
Date Available 2012-02-13T05:06:23Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Cellular Interactions (incl Adhesion, Matrix, Cell Wall); Structural Biology (incl Macromolecular Modelling); Theoretical and Computational Chemistry
URI http://hdl.handle.net/10072/42472
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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