Recent advances in mapping the sub-cellular distribution of metal-based anticancer drugs

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Title Recent advances in mapping the sub-cellular distribution of metal-based anticancer drugs
Author Wedlock, Louise; Berners-Price, Sue
Journal Name Australian Journal of Chemistry
Year Published 2011
Place of publication Australia
Publisher CSIRO PUBLISHING
Abstract here are increasing reports of novel metal-based chemotherapeutics that have either improved cancer cell selectivity, or alternative mechanisms of action, to existing anticancer drugs, and techniques are required for determining their sub-cellular molecular targets. Imaging methods offer many distinct advantages over destructive fractionation techniques, including the preservation of useful morphological information; however, mapping the intracellular distribution of metal ions inside tumour cells still remains challenging. Recent advances in three modes of imaging are discussed in this review, with a particular focus on the application to metal-based cancer chemotherapy – fluorescence microscopy, electron microscopy (including energy-filtered transmission electron microscopy (EFTEM)), and a new technique, Nano-scale secondary ion mass spectrometry (NanoSIMS).
Peer Reviewed Yes
Published Yes
Alternative URI http://www.publish.csiro.au/paper/CH11132.htm
Volume 64
Issue Number 6
Page from 692
Page to 704
ISSN 0004-9425
Date Accessioned 2012-01-28; 2012-02-14T04:10:57Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Bioinorganic Chemistry
URI http://hdl.handle.net/10072/42567
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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