Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells

There are no files associated with this record.

Title Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells
Author Farina, Antonietta R.; Cappabianca, Lucia; DeSantis, Giuseppina; Ianni, Natalia Di; Ruggeri, Pierdomenico; Ragone, Marzia; Merolle, Stefania; Tonissen, Kathryn Fay; Gulino, Alberto; Mackay, Andrew R.
Journal Name FEBS Letters
Editor Felix Wieland
Year Published 2011
Place of publication Netherlands
Publisher Elsevier
Abstract Increased expression of thioredoxin (Trx)-1 and matrix metalloproteinase (MMP)-9 associates with malignant breast cancer progression. Here, we describe a functional relationship between Trx-1 and MMP-9 in promoting MDA-MB-231 breast cancer cell invasive behaviour. Trx-1 overexpression stimulated MMP-9 expression, de-regulated the MMP-9/TIMP-1 equilibrium and augmented MMP-9 involvement in a more invasive phenotype. Trx-1 augmented MMP-9 transcription through NF-B, AP-1 and SP1 elements; stimulated p50/p65 NF-kB activity and recruitment to the MMP-9 promoter; and facilitated MMP-9 promoter-accessibility to NF-kB by preventing HDAC recruitment and maintaining MMP-9 promoter histone acetylation. Our data provide a functional basis for Trx-1 and MMP-9 association in malignant breast cancer and identify Trx-1 and NF-kB as potentiallydruggable targets for reducing MMP-9 involvement in malignant behaviour.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.febslet.2011.09.023
Volume 585
Issue Number 20
Page from 3328
Page to 3336
ISSN 0014-5793
Date Accessioned 2011-10-13; 2012-02-14T05:36:15Z
Date Available 2012-02-14T05:36:15Z
Research Centre Eskitis Institute for Drug Discovery
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Cancer Cell Biology; Cellular Interactions (incl Adhesion, Matrix, Cell Wall)
URI http://hdl.handle.net/10072/42606
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

Brief Record

Griffith University copyright notice