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dc.contributor.authorFarina, Antonietta R
dc.contributor.authorCappabianca, Lucia
dc.contributor.authorDeSantis, Giuseppina
dc.contributor.authorDi Ianni, Natalia
dc.contributor.authorRuggeri, Pierdomenico
dc.contributor.authorRagone, Marzia
dc.contributor.authorMerolle, Stefania
dc.contributor.authorTonissen, Kathryn F
dc.contributor.authorGulino, Alberto
dc.contributor.authorMackay, Andrew R
dc.contributor.editorFelix Wieland
dc.date.accessioned2017-05-03T13:22:19Z
dc.date.available2017-05-03T13:22:19Z
dc.date.issued2011
dc.date.modified2012-02-14T05:36:15Z
dc.identifier.issn0014-5793
dc.identifier.doi10.1016/j.febslet.2011.09.023
dc.identifier.urihttp://hdl.handle.net/10072/42606
dc.description.abstractIncreased expression of thioredoxin (Trx)-1 and matrix metalloproteinase (MMP)-9 associates with malignant breast cancer progression. Here, we describe a functional relationship between Trx-1 and MMP-9 in promoting MDA-MB-231 breast cancer cell invasive behaviour. Trx-1 overexpression stimulated MMP-9 expression, de-regulated the MMP-9/TIMP-1 equilibrium and augmented MMP-9 involvement in a more invasive phenotype. Trx-1 augmented MMP-9 transcription through NF-B, AP-1 and SP1 elements; stimulated p50/p65 NF-kB activity and recruitment to the MMP-9 promoter; and facilitated MMP-9 promoter-accessibility to NF-kB by preventing HDAC recruitment and maintaining MMP-9 promoter histone acetylation. Our data provide a functional basis for Trx-1 and MMP-9 association in malignant breast cancer and identify Trx-1 and NF-kB as potentially druggable targets for reducing MMP-9 involvement in malignant behaviour.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom3328
dc.relation.ispartofpageto3336
dc.relation.ispartofissue20
dc.relation.ispartofjournalFEBS Letters
dc.relation.ispartofvolume585
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchCellular interactions (incl. adhesion, matrix, cell wall)
dc.subject.fieldofresearchEvolutionary biology
dc.subject.fieldofresearchCancer cell biology
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310105
dc.subject.fieldofresearchcode3104
dc.subject.fieldofresearchcode321101
dc.titleThioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorTonissen, Kathryn F.


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