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dc.contributor.authorLutton, Cameron
dc.contributor.authorYoung, Yun Wai
dc.contributor.authorWilliams, Richard
dc.contributor.authorMeedeniya, Adrian CB
dc.contributor.authorMackay-Sim, Alan
dc.contributor.authorGoss, Ben
dc.date.accessioned2017-05-03T15:06:18Z
dc.date.available2017-05-03T15:06:18Z
dc.date.issued2012
dc.date.modified2013-09-11T23:25:43Z
dc.identifier.issn0897-7151
dc.identifier.doi10.1089/neu.2010.1423
dc.identifier.urihttp://hdl.handle.net/10072/42644
dc.description.abstractTrauma to the spinal cord creates an initial physical injury damaging neurons, glia and blood vessels, which then induces a prolonged inflammatory response leading to secondary degeneration of spinal cord tissue and further loss of neurons and glia surrounding the initial site of injury. Angiogenesis is a critical step in tissue repair but in the injured spinal cord angiogenesis fails; blood vessels formed initially, later regress. Stabilizing the angiogenic response is therefore a potential target to improve recovery after for spinal cord injury. Vascular Endothelial Growth Factor (VEGF) can initiate angiogenesis but cannot sustain blood vessel maturation. Platelet Derived Growth Factor (PDGF) can promote blood vessel stability and maturation. We therefore investigated a combined application of VEGF and PDGF as treatment for traumatic spinal cord injury, with the aim to reduce secondary degeneration by promotion of angiogenesis. Immediately after hemi-section of the spinal cord in the rat we delivered VEGF and PDGF and to the injury site. One and three months later the size of the lesion was significantly smaller in the treated group compared to controls and there was significantly reduced gliosis surrounding the lesion. There was no significant effect of the treatment on blood vessel density, although there was a significant reduction in the numbers of macrophages/microglia surrounding the lesion, and a shift in the distribution of morphological and immunological phenotypes of these inflammatory cells. VEGF and PDGF delivered singly exacerbated the secondary degeneration, increasing the size of the lesion cavity. These results demonstrate a novel therapeutic intervention for spinal cord injury and reveal an unanticipated synergy for these growth factors whereby they modulated inflammatory processes and create a microenvironment conducive to axon preservation/sprouting.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent14805116 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc. Publishers
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom957
dc.relation.ispartofpageto970
dc.relation.ispartofissue5
dc.relation.ispartofjournalJournal of Neurotrauma
dc.relation.ispartofvolume29
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCentral nervous system
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320903
dc.titleCombined VEGF and PDGF Treatment Reduces Secondary Degeneration after Spinal Cord Injury
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightThis is a copy of an article published in the Journal of Neurotrauma. Copyright 2011 Mary Ann Liebert, Inc. Journal of Neurotrauma is available online at: http://www.liebertonline.com
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorMackay-Sim, Alan


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